Publications by authors named "Bassam M Smadi"
Development of Biomaterials for Addressing Upper Extremity Peripheral Nerve Gaps.
J Hand Surg Glob Online
September 2024
Article Synopsis
- Peripheral nerve injuries in the upper extremities can significantly impair function and lower quality of life, prompting the need for effective treatments.
- Traditional nerve repair methods, like autografts, have downsides such as donor site morbidity, leading to interest in using biomaterials as alternatives.
- This review discusses the evolution, current usage, benefits, challenges, and future prospects of biomaterials in nerve regeneration, highlighting their transformative potential in improving clinical outcomes.
Every year, there are approximately 500 000 peripheral nerve injury (PNI) procedures due to trauma in the US alone. Autologous and acellular nerve grafts are among current clinical repair options; however, they are limited largely by the high costs associated with donor nerve tissue harvesting and implant processing, respectively. Therefore, there is a clinical need for an off-the-shelf nerve graft that can recapitulate the native microenvironment of the nerve.
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