Publications by authors named "Basma S Haggag"
Article Synopsis
- Various antiepileptic drugs, particularly those that induce enzymes, might increase vascular risks by impairing the body’s natural antioxidant abilities, leading to tissue damage; however, the effects of the non-enzyme-inducing drug lamotrigine (LTG) on oxidative stress have been less studied.
- A study was conducted using male Wister rats divided into four groups to investigate the impact of LTG on vascular risk factors in a model of seizures, examining levels of lipoproteins, homocysteine, malondialdehyde, and glutathione over five weeks.
- Results indicated that epileptic rats exhibited higher levels of harmful substances and lower beneficial lipoproteins compared to controls, but LTG treatment resulted in improved seizure severity