Publications by authors named "Basma B Khalefa"
Background: Hyperphosphatemia is common in chronic kidney disease (CKD) patients, especially patients on hemodialysis. Tenapanor is a novel drug with fewer side effects and high compliance compared to traditional phosphate binders. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of tenapanor.
View Article and Find Full Text PDFSelf-Expandable Versus Balloon-Expandable Transcatheter Aortic Valve Replacement for Treatment of Patients With Small Aortic Annulus: An Updated Meta-Analysis of Reconstructed Individual Patient Data.
Cardiol Rev
December 2024
Transcatheter aortic valve replacement has emerged as an effective alternative to surgery in selected patients with aortic stenosis. It needs to be made clear which type of valve has better results in patients with small aortic annulus. We searched PubMed, Scopus, Embase, Cochrane Library, and Web of Science, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.
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- Patients with congenital heart disease (CHD) have a significantly increased risk of both ischemic and hemorrhagic strokes, with pooled hazard ratios showing they are over three times more likely to experience strokes compared to non-CHD patients.
- A systematic review analyzed data from eleven studies involving over 5 million participants to assess stroke risks associated with CHD and found higher risks particularly in Europe and among adults rather than children.
- The study suggests a need for more targeted research to address identified regional and data gaps, which could improve clinical approaches to managing stroke risk in CHD patients.
Background: Mpox infection is a zoonotic illness that resembles smallpox. Vaccination is widely regarded as a vital effective method of preventing mpox, however, there is lack of consensus of effectiveness of a single dose of mpox vaccine in the current 2022-2023 outbreak. We pooled data from real-world studies to evaluate the efficacy of the JYNNEOS vaccination given as a single dosage.
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- TAVR (transcatheter aortic valve replacement) offers treatment for severely ill patients, but outcomes for those with cardiogenic shock (CS) are not well understood.
- A meta-analysis of five studies showed that 30-day mortality and major vascular complications were significantly higher in patients with CS compared to those without, but there were no significant differences in longer-term outcomes at one year.
- The study suggests that while short-term risks are elevated for TAVR patients with CS, their long-term prognosis may be similar to those without CS; further research is needed to explore the timing and management strategies of TAVR for this group.
Introduction: While right ventricular pacing (RVP) is the conventional temporary pacing modality used for transcatheter aortic valve replacement (TAVR), this approach possesses inherent risks and procedural challenges. We aim to assess and compare the safety and efficacy of left ventricular pacing (LVP) and RVP during TAVR and balloon aortic valvuloplasty (BAV).
Methods: Following PRISMA guidelines, a comprehensive literature search was conducted in four databases from inception to December 15th, 2023.
Multiple arterial conduit revascularization in coronary bypass surgery is being advocated over the use of venous conduits. However, there is a critical gap regarding the optimal sequence of arterial conduit selection following the left internal thoracic artery. This study is the first individual patient data meta-analysis, which aimed to compare the right internal thoracic artery (RITA) versus the radial artery (RA) as a second-best arterial conduit.
View Article and Find Full Text PDFIntroduction: Patients with a small aortic annulus (SAA) undergoing aortic valve replacement are at increased risk of patient-prosthesis mismatch (PPM), which adversely affects outcomes. Transcatheter aortic valve replacement (TAVR) has shown promise in mitigating PPM compared to surgical aortic valve replacement (SAVR).
Methods: We conducted a systematic review and meta-analysis following PRISMA guidelines to compare clinical outcomes, mortality, and PPM between SAA patients undergoing TAVR and SAVR.
This systematic review aims to consolidate findings from current clinical trials that compare the effectiveness of insulin infusion at 0.05 IU/kg/h versus 0.1 IU/kg/h in managing pediatric diabetic ketoacidosis.
View Article and Find Full Text PDFTranscatheter aortic valve implantation versus surgical aortic valve replacement for pure aortic regurgitation: a systematic review and meta-analysis of 33,484 patients.
BMC Cardiovasc Disord
January 2024
Article Synopsis
- - This systematic review compared transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) specifically for patients with pure aortic regurgitation, highlighting conflicting previous studies.
- - The analysis included data from six studies involving over 33,000 patients and found comparable in-hospital mortality rates but significantly lower rates of stroke, acute kidney injury, and major bleeding with TAVI.
- - Although TAVI led to better safety outcomes and shorter hospital stays, it also resulted in a higher rate of pacemaker implantation compared to SAVR.
Two-incision versus three-incision implantation technique of subcutaneous implantable cardioverter defibrillator: Systematic review and meta-analysis of 2076 patients.
Pacing Clin Electrophysiol
February 2024
Introduction: The implantable cardioverter-defibrillator (ICD) was designed to detect and treat ventricular arrhythmias, which account for nearly half of all cardiovascular fatalities. Transvenous ICD (TV-ICD) complications were reduced by introducing subcutaneous ICD (S-ICD). S-ICD can be implanted using a three (3IT)- or two (2IT)-incision technique.
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