Persistent corneal fibrosis after explantation of a small-aperture corneal inlay.

The KAMRA small-aperture corneal inlay can compensate for presbyopia. A small number of complications have been reported, including glare, halos, decentration, iron deposition, compromised distance and night vision, infectious keratitis and reversal corneal haze. We describe a case of corneal fibrosis after small-aperture corneal inlay implantation and its persistence after late explantation.

Conventional and Iontophoresis Corneal Cross-Linking for Keratoconus: Efficacy and Assessment by Optical Coherence Tomography and Confocal Microscopy.

Purpose: To compare the efficacy, safety, and microstructural corneal changes during 2 years after conventional corneal collagen cross-linking (C-CXL) and transepithelial corneal CXL by iontophoresis (I-CXL) for keratoconus.

Methods: Eighty eyes of 80 patients with progressive keratoconus were treated by C-CXL (n = 40) or I-CXL (n = 40). Patients were investigated before surgery and 1, 3, 6, 12, and 24 months after treatment.

Anatomic Predictive Factors of Acute Corneal Hydrops in Keratoconus: An Optical Coherence Tomography Study.

Purpose: To define the optical coherence tomography (OCT) corneal changes predisposing to acute corneal hydrops among patients with advanced keratoconus.

Design: Retrospective cohort study.

Participants: A total of 191 advanced keratoconic eyes from 191 patients with advanced keratoconus cases were studied.

[Corneal collagen crosslinking in keratoconus].

Corneal collagen crosslinking (CXL) is, at present, the only treatment that can slow or even stop the progression of keratoconus. It uses riboflavin and ultraviolet A (UVA) to create covalent bonds ("crosslinks") between collagen fibrils thus increasing corneal rigidity. Although to date there has been no direct evidence of intrastromal corneal crosslinking, several studies have reported the safety and efficacy of the conventional CXL protocol.

Corneal epithelial thickness mapping using Fourier-domain optical coherence tomography for detection of form fruste keratoconus.

Purpose: To determine whether optical coherence tomography (OCT) epithelial mapping can improve the detection of form fruste keratoconus.

Setting: French National Eye Hospital, Paris 6 Pierre & Marie Curie University, Paris, France.

Design: Retrospective comparative study.

Fourier-domain optical coherence tomography imaging in corneal epithelial basement membrane dystrophy: a structural analysis.

Purpose: To investigate the features of corneal epithelial basement membrane dystrophy using spectral-domain optical coherence tomography (SD OCT) and to examine the reliability of SD OCT in distinguishing epithelial basement membrane dystrophy from the normal cornea.

Design: Diagnostic test study.

Methods: Forty-five individuals with epithelial basement membrane dystrophy and 45 age- and sex-matched controls with normal corneas were examined, and SD OCT scans of their corneas were performed.

Optical coherence tomography and confocal microscopy following three different protocols of corneal collagen-crosslinking in keratoconus.

Purpose: We compared the efficacy and early morphological changes in the cornea following conventional (C-CXL), transepithelial by iontophoresis (I-CXL), and accelerated (A-CXL) collagen cross-linking in keratoconus.

Methods: A total of 45 eyes of 45 patients with progressive keratoconus who underwent corneal collagen crosslinking (CXL) was divided into three groups: C-CXL (n = 15), A-CXL (n = 15), and I-CXL (n = 15). Patients were examined before surgery and at 1-, 3-, and 6-month intervals following surgery.

Fourier-domain optical coherence tomography imaging in keratoconus: a corneal structural classification.

Objective: To study corneal morphologic changes in a large keratoconic population and to establish a structural optical coherence tomography (OCT) classification.

Design: Cross-sectional, observational study.

Participants: A total of 218 keratoconic eyes from 218 patients and 34 eyes from 34 normal subjects.

[Epithelial basement membrane dystrophy diagnosed following LASIK surgery].

A 48-year-old woman with no significant past history underwent bilateral simultaneous laser in situ keratomileusis for correction of her myopia. On the tenth postoperative day, the patient complained of visual decrease and photophobia. Slit lamp exam showed corneal epithelial irregularities.

Epiretinal membrane recurrence: incidence, characteristics, evolution, and preventive and risk factors.

Background: To evaluate the incidence, evolution, clinical characteristics, possible risk factors or preventive factors, and visual outcomes of epiretinal membrane (ERM) recurrence.

Methods: Retrospective study of 440 consecutive patients (440 eyes) who underwent pars plana vitrectomy for ERM. The internal limiting membrane (ILM) was peeled in 266 cases, with the help of indocyanine green in 27 cases and brilliant blue in 45 cases.

Donor tissue selection for anterior lamellar keratoplasty.

Purpose: To assess the influence of donor characteristics on the outcome of anterior lamellar keratoplasty (ALK) and to evaluate whether corneal donor tissue considered unsuitable for penetrating or posterior lamellar keratoplasty due to poor endothelial condition may be safely used for ALK.

Methods: Institutional setting. One hundred sixty-six consecutive ALK (166 patients) performed for optical indication in eyes with corneal diseases not involving the corneal endothelium.

Long-term rejection incidence and reversibility after penetrating and lamellar keratoplasty.

Purpose: To identify risk factors for corneal graft rejection and rejection irreversibility.

Design: Retrospective cohort study.

Methods: setting: Institutional.

Paracentral retinal holes occurring after macular surgery: incidence, clinical features, and evolution.

Aim: To describe the incidence, clinical features, and evolution of paracentral retinal holes occurring after macular surgery.

Methods: A retrospective non-randomized study of 909 patients operated on for either a macular hole (MH, n = 400 patients) or an epiretinal membrane (ERM, n = 509 patients) between 2004 and 2009. Six patients (0.

25-, 23-, and 20-gauge vitrectomy in epiretinal membrane surgery: a comparative study of 553 cases.

Purpose: To compare the safety and functional outcomes of 25-gauge and 23-gauge (G) micro-incision vitrectomy surgery (MIVS) instrumentation with the standard 20-G vitrectomy system in the treatment of epiretinal membranes (ERM).

Methods: A retrospective comparative study of 553 consecutive cases with epiretinal membrane who underwent pars plana vitrectomy. Twenty-gauge, 25-gauge and 23-gauge vitrectomy was performed respectively in 347, 91, and 115 eyes.

[Recurrence of an idiopathic vasocentric epiretinal membrane: clinical and surgical particularities].

The vasocentric epiretinal membranes (ERM) are idiopathic ERM centered on retinal blood vessels, described mainly in young patients. We report a case of a 70-year-old patient who presented with a decrease in visual acuity secondary to a vasocentric epiretinal membrane. A successful vitrectomy and ERM removal were performed.

Human epithelial cell cultures from superficial limbal explants.

Purpose: To study the kinetics of growth and the phenotype of cells cultured from human limbal explants in a cholera toxin-free medium with no feeder cell layer.

Methods: Human organ-cultured corneas were used to prepare limbal explants (full-thickness and superficial limbal explants) and corneal stromal explants. Cell growth kinetics and phenotypes were assessed by cultivating explants in cholera toxin-free Green medium.

[Human limbal epithelial cell growth kinetics in vitro].

Purpose: To assess limbal epithelial cell growth kinetics in vitro using tissue retrieved from organ-cultured donor corneas.

Patients And Methods: Twenty-one limbal explants were retrieved from corneoscleral rims of donor corneal grafts preserved for 18-24 days in organ culture. The explants were cultured at 37°C for 10, 13, or 18 days.

New test for the diagnosis of bacterial endophthalmitis.

Background: Diagnosis of bacterial endophthalmitis (BE) often fails due to: (1) insufficient volumes of vitreous fluid (VF) and aqueous humour (AH); (2) lack of sensitivity of culture; (3) antibiotic treatments; (4) polymerase chain reaction (PCR) cross-contamination; and (5) limitations on the interpretation of the real-time PCR melting curve. We developed a fast real-time (f-real-t) PCR to improve the performance of the laboratory diagnosis of BE.

Methods: The following samples were processed after adding an internal control: phosphate buffered saline (PBS); VF, AH and cell suspensions spiked with Bacteria (Bac); VF and AH from patients with endophthalmitis; and VF and AH from non-infective patients.