Synopsis of recent research by authors named "Basil Bakir"
- Basil Bakir's recent research predominantly focuses on pancreatic cancer, particularly the mechanisms of tumor growth and metastasis related to RAS mutations, with findings indicating that RMC-7977, a selective RAS inhibitor, has potential significant therapeutic benefits in treating pancreatic ductal adenocarcinoma (PDAC).
- Findings from Bakir's studies highlight the critical roles of epithelial plasticity and specific proteins, such as PTHrP and ETV1, in driving pancreatic cancer growth and metastasis, suggesting new therapeutic vulnerabilities and approaches to treatment.
- Bakir has also advanced the understanding of pancreatic cancer through innovative research models like 3D organoids, enhancing the potential for personalized medicine in combating this aggressive cancer type.
