Publications by authors named "Basil Alotaibi"
Genomic instability is one of the main drivers of tumorigenesis and the development of hematological malignancies. Cancer cells can remedy chemotherapeutic-induced DNA damage by upregulating DNA-repair genes and ultimately inducing therapy resistance. Nevertheless, the association between the DNA-repair genes, drug resistance, and disease relapse has not been well characterized in acute lymphoblastic leukemia (ALL).
View Article and Find Full Text PDFArticle Synopsis
- The study explores the quality of life (QoL) among cancer patients, highlighting how it affects their treatment response and mortality rates, with the aim of improving their experience through targeted interventions.
- Conducted with 182 cancer patients using questionnaires, the research found that younger patients and single individuals reported better physical QoL, while females faced more adverse symptoms and asthmatics had significantly lower QoL in multiple areas.
- The findings indicate that factors like age, gender, marital status, hospital distance, and existing health issues play crucial roles in QoL, suggesting a need for personalized care strategies in cancer treatment in Saudi Arabia.
This study aimed to conduct a methodological review of drug-related toxicological studies in Saudi Arabia. A systematic review and a methodological analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Medline and Embase were searched for all types of studies reporting toxicological studies in the English language published until January 10, 2022.
View Article and Find Full Text PDFAims: Diabetes mellitus (DM) and atrial fibrillation (AF) commonly co-exist. Oral anticoagulants (OACs) are widely used in patients with DM. This review aims to summarise the available literature on the safety (hypoglycaemia or bleeding) and efficacy (stroke or systemic embolism) of the use of OACs in patients with DM.
View Article and Find Full Text PDFAims: The prevalence of CKD in patients with diabetes mellitus in the Middle East region is unknown. Therefore, we aimed to understand the pooled prevalence of CKD in patients with diabetes mellitus in the Middle East region.
Methods: PubMed, Embase, and Cochrane databases were searched for relevant studies up to October 2020.
Background: COVID-19 pandemic is a major strain on health and economic systems, with rapidly increasing demand for in patients' facilities. Disease diagnosis and estimating patients at higher risk is important for the optimal management during the pandemic. This study aimed to identify the predictors of mortality and length of hospital stay in COVID-19 patients.
View Article and Find Full Text PDFinfection is one of the most common causes of gastroenteritis worldwide. It is associated with high morbidity and mortality if not treated properly. It has developed resistance to multiple antibiotics.
View Article and Find Full Text PDF