Structure prediction, molecular simulations of RmlD from Mycobacterium tuberculosis, and interaction studies of Rhodanine derivatives for anti-tuberculosis activity.

Tuberculosis is the most dangerous disease causing maximum deaths than any other, caused by single infectious agent. Due to multidrug resistant of Mycobacterium tuberculosis strains, there is a need of new drugs and drug targets. In this work, we have selected RmlD (α-dTDP-6-deoxy-lyxo-4-hexulose reductase) in the dTDP Rhamnose pathway as drug target to control tuberculosis using Rhodanine analogues.

ITS 2 and RNA secondary structure-based analysis reveals a clear picture on phylogeny of South Indian Salacia spp.

The genus Salacia (Celastraceae) consists of many important medicinal plants used mainly against type II diabetes. Segregation and delimitation of species is difficult based on morphological features alone. DNA barcoding is the most effective and emerging method of molecular identification.

Effect of Submandibular Fossa on Implant Length in the Posterior Mandibular Region.

This retrospective study aims to evaluate the association between submandibular fossa anatomy and implant length in the posterior mandibular region. The study took place from June 1, 2019 to March 1, 2020, during which 295 implants were placed in the posterior mandibular region. Data were reviewed and analyzed from 86,000 patient records that were documented at a private institution.

Diagnostic Modalities for the Detection of SARS-CoV-2: Principles, Advantages, and Pitfalls.

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a significant worldwide health concern in recent months. The world has not dealt with such adversities since World War II. The spread has had a devastating and massive impact on global health, the economy, and people's everyday lives.

Two-Year Prevalence of Rotavirus Among Under-Five Children Admitted with Acute Gastroenteritis in Andhra Pradesh, India.

Objective: To estimate the burden of rotavirus diarrhea among under-five children admitted with acute gastroenteritis and to identify genotypes of rotavirus among positive rotavirus cases.

Methods: This is a cross-sectional study conducted from August 2017 to July 2019 in Government General Hospital and 5 private pediatric nursing homes (Padma Children's Hospital, Mother and Child Hospital, Chandamama Children's Hospital, Vennela Hospital) in Kakinada. Children admitted to the pediatric ward with acute gastroenteritis were included in this study.

Hearing outcome in infants following correction of maternal hypothyroidism during pregnancy.

Purpose: There is significant prevalence of overt and subclinical hypothyroidism in pregnant women in rural areas. Maternal hypothyroidism is known to cause congenital hypothyroidism resulting in sensorineural hearing loss. Anti-Thyroperoxidase antibodies are known to cross placental barrier.

Rotavirus Gastroenteritis Hospitalizations Among Under-Five Children in Bhubaneswar, Odisha, India.

Objective: To report rotavirus-associated AGE (AGE) profile of admitted children among vaccine-introduced areas in Bhubaneswar, Odisha.

Methods: This study was conducted between 2016 and 2019 at the Capital Hospital, Jagannath hospital and Hi-Tech Medical College and Hospital. All AGE patients below five years old, hospitalized in the study facilities were enrolled.

Implementation of the new integrated algorithm for diagnosis of drug-resistant tuberculosis in Karnataka State, India: How well are we doing?

Background: As per national policy, all diagnosed tuberculosis patients in India are to be tested using Xpert® MTB/RIF assay at the district level to diagnose rifampicin resistance. Regardless of the result, samples are transported to the reference laboratories for further testing: first-line Line Probe Assay (FL-LPA) for rifampicin-sensitive samples and second-line LPA(SL-LPA) for rifampicin-resistant samples. Based on the results, samples undergo culture and phenotypic drug susceptibility testing.

A Novel Way of Standardization of ICG Lymphangiography Reporting.

 Indocyanine green (ICG) lymphangiography is being increasingly employed to assess the severity of lymphedema, locate the areas of patent linear lymphatics and dermal backflow and plan treatment. This study suggests a novel method of reporting ICG findings in extremities to enable easy understanding among surgeons and physiotherapists and avoid repeat testing when a patient visits a disparate lymphedema center or clinician.  A reporting protocol was developed in the lymphedema clinic of the plastic surgery department, and patients were asked to bring along the report in every subsequent review.

LESS THAN HALF OF ACL-RECONSTRUCTED ATHLETES ARE CLEARED FOR RETURN TO PLAY BASED ON PRACTICE GUIDELINE CRITERIA: RESULTS FROM A PROSPECTIVE COHORT STUDY.

Background: A recently published Dutch practice guideline emphasizes criterion-based rehabilitation after anterior cruciate ligament reconstruction (ACLR) instead of time-based. As a consequence of this criterion-based rehabilitation, return to play is only suggested when athletes meet specific return to play (RTP) criteria.

Purpose: The goal of this prospective observational study was to analyze if physical therapists adhere to ACLR practice guideline RTP criteria for testing and return to sport decisions, and to explore whether there is a difference in adherence between physical therapists specialized in sports versus those who are not.

Study of dynamics of genes involved in biosynthesis and accumulation of scopoletin at different growth stages of Convolvulus prostratus Forssk.

The scopoletin one of the major bioactive components of Convolvulus prostratus Forssk known to have a role in acetylcholinesterase inhibitor, memory enhancer, antimicrobial, antioxidative etc. properties are investigated in the present study. The concentration of scopoletin in C.

Designing complex radial heterostructures of Te/BiTe and Te/Bi Pb Te nanowires: fundamental mechanistic insights into nanowire growth and evolution.

Metal telluride/Te heterostructure nanowires are important thermoelectric materials and it is important to be able to tune these materials according to the requirement of the application. In order to do so, a good understanding of the reaction mechanism and critical observation of the evolution of the nanowire heterostructure during the course of reaction is essential. Here, single crystalline, anisotropic Te core/BiTe shell nanowires have been synthesized by a facile template-based wet chemical synthesis method.

Glucodynamics and glucocracy in type 2 diabetes mellitus: clinical evidence and practice-based opinion on modern sulfonylurea use, from an International Expert Group (South Asia, Middle East & Africa) via modified Delphi method.

Type 2 diabetes mellitus (T2DM) is a global epidemic. According to international guidelines, the management protocol of T2DM includes lowering of blood glucose, along with preventing disease-related complications and maintaining optimal quality of life. Further, the guidelines recommend the use of a patient-centric approaches for the management of T2DM; however, Asian population is underrepresented in landmark cardiovascular outcome trials (CVOTs).

An ultra-sensitive and selective AChE based colorimetric detection of malathion using silver nanoparticle-graphene oxide (Ag-GO) nanocomposite.

Herein, we propose rapid, precise acetylcholinesterase (AChE) inhibition-based sensing strategy for malathion detection in the presence of Ag-GO and acetylthiocholine (ATCh). The biosensing method was developed with a nanocomposite of citrate stabilized AgNPs anchored on the GO sheets (Ag-GO). The physical and chemical properties of the prepared Ag-GO composite were analyzed with various characterization techniques, including XRD, FT-IR, XPS, UV-Visible spectroscopy, and HR-TEM.

Factors influencing pregnancy planning of multi-ethnic Asian women with diabetes: A qualitative study.

Introduction: Pregnancy planning varies among women with diabetes. Observing that the literature examining the factors affecting diabetic women's pregnancy intentions in multi-ethnic Asian populations is limited, we sought to explore these factors to give a better perspective on these women's pregnancy planning.

Methods: This qualitative study used individual in-depth interviews to capture the views and experiences of non-pregnant diabetic women of reproductive age in four public health clinics in a southwestern state of peninsular Malaysia from May 2016 to February 2017.

Translation Initiation Control of RNase E-Mediated Decay of Polycistronic mRNA.

In bacteria, mRNA decay is a major mechanism for regulating gene expression. In , mRNA decay initiates with endonucleolytic cleavage by RNase E. Translating ribosomes impede RNase E cleavage, thus providing stability to mRNA.

Role of health insurance and neighborhood-level social deprivation on hypertension control following the affordable care act health insurance opportunities.

Objectives: To understand if neighborhood-level social deprivation moderates the association between gaining health insurance and improved hypertension control.

Methods: We used electronic health record (EHR) data from the Accelerating Data Value Across a National Community Health Center Network (ADVANCE) clinical data research network from five states that expanded Medicaid eligibility (CA, OH, OR, WA, WI). We include patients with hypertension aged 19-64.

Phototherapy and Sonotherapy of Melanoma Cancer Cells Using Nanoparticles of Selenium-Polyethylene Glycol-Curcumin as a Dual-Mode Sensitizer.

Background: As an alternative form of cancer therapy, photothermal therapy (PTT) and sonodynamic therapy (SDT) using nanomaterials are in development. Nanomaterials can act as energy absorber as well as anti-cancer agent.

Objective: In this study, the effects of laser and ultrasound irradiation with Se-PEG-Cur nanoparticles were investigated on melanoma cancer.

Effect of Neodymium Doping on MRI Relaxivity of Gadolinium Oxide Nanoparticles.

Background: Gadolinium oxide nanoparticles as positive contrast material of magnetic resonance imaging (MRI) have attracted a great attention due to the appropriate magnetic properties. One of the most desirable features of these nanoparticles is their ability of doping with other lanthanides which can change their properties.

Objective: This study aimed to investigate the effect of neodymium doping on MRI relaxivity of the gadolinium oxide nanoparticles.

Vertebral Artery Injury in Cervical Spine Fractures: A Cohort Study and Review of the Literature.

Background: The risk of vertebral artery injury (VAI) secondary to cervical spine fracture is increasingly recognised in the literature. The aim of this study was to determine the incidence of VAI amongst patients presenting to the Royal Victoria Hospital (Northern Ireland's regional trauma centre with emergency surgical spinal services) with acute cervical spine fractures, and to identify fracture patterns associated with the highest risk of VAI.

Methods: A retrospective review of 1,894 computed tomography (CT) reports of patients who underwent imaging of their cervical spine and/or vertebral arteries over a 12-month period, from June 2018 to June 2019, was conducted.

Pulsed exposure of the macrophyte Lemna minor to herbicides and the mayfly Neocloeon triangulifer to diamide insecticides.

Pesticides applied to agricultural land can enter aquatic ecosystems through runoff or leaching during precipitation events. In a lotic system, these events result in a pulse of exposure to biota living in these systems. The concentration of pesticide increases, peaks, and then gradually declines, and this pulsed exposure may occur multiple times over the course of a growing season.

Prospection of recent chitosan biomedical trends: Evidence from patent analysis (2009-2020).

Improved accuracy is one of the vital innovations in designing biopolymer-based products that are gaining momentum in diverse biomedicine arenas. The innovative devices were developed utilizing synthetic polymers but now are replaced with 'green polymer' such as chitosan. These bioactive polymer-based products can control release therapeutics, even greatly minimize the post-surgery inflammations, immune responses, and are biodegradable.