Identification of functional tumor necrosis factor-alpha promoter variants associated with infection in the Sudanese population: Computational approach.

Background: () is a ubiquitous bacterium that affects nearly half of the world's population with a high morbidity and mortality rate. Polymorphisms within the tumor necrosis factor-alpha () promoter region are considered a possible genetic basis for this disease.

Aim: To functionally characterize the genetic variations in the 5'-region (-584 to +107) of Sudanese patients infected with using in silico tools.