A dramatic response to checkpoint inhibitor in a woman with small cell carcinoma of the hypercalcemic type of the ovary.

Objective: We present the rare case of a 21 year old woman with small cell carcinoma of the right ovary of the hypercalcemic type with dramatic response to checkpoint inhibitor.

Methods: Case report.

Results And Conclusions: Our patient, a 22-year old woman with small cell carcinoma of the hypercalcemic type with hepatic metastases, is currently 43 months under treatment with pembrolizumab.

Reversible Intercalation of Li Ions in an Earth-Abundant Phyllosilicate Clay.

The phyllosilicate family of clays is an intriguing collection of materials that make ideal models for studying the intercalation of alkali ions due to their layered topology and broadly tunable composition space. In this spirit, we present a hydrothermal method to prepare a layered iron phyllosilicate clay, FeSiO(OH), and an evaluation of its electrochemical performance for the (de)insertion of Li ions. Through careful structural refinement, we determined that this iron clay contains a 2:1 stacking sequence, which is directly analogous to the widely studied mineral montmorillonite, with the crystallites adopting a platelike morphology.

Multielectron, Cation and Anion Redox in Lithium-Rich Iron Sulfide Cathodes.

Conventional Li-ion cathodes store charge by reversible intercalation of Li coupled to metal cation redox. There has been increasing interest in new materials capable of accommodating more than one Li per transition-metal center, thereby yielding higher charge storage capacities. We demonstrate here that the lithium-rich layered iron sulfide LiFeS as well as a new structural analogue, LiNaFeS, reversibly store ≥1.

Hydrothermal Preparation, Crystal Chemistry, and Redox Properties of Iron Muscovite Clay.

The development of functional materials based on Earth-abundant, environmentally benign compositions is critical for ensuring their commercial viability and sustainable production. Here we present an investigation into the crystal chemistry and electrochemical properties of the muscovite clay KFeSiO(OH). We first report a low-temperature hydrothermal reaction that allows for a significant degree of control over sample crystallinity, particle morphology, and cation distribution through the lattice.