Publications by authors named "Basch E"

Background: Composting is a practical solution to the burgeoning global problem of food waste, which is a significant contributor to landfills and associated environmental effects. Dissemination of accurate information regarding the microbial-driven composting process is critical to positive outcomes.

Aim: To describe the content of news articles addressing composting.

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Purpose: Remote symptom monitoring (RSM) using electronic patient-reported outcomes (ePROS) connects patients and health care teams between appointments. Patient-perceived benefits and drawbacks of RSM are well-known, but health care team members' perceptions are less clear.

Methods: Health care team members from the University of Alabama at Birmingham and the University of South Alabama Health Mitchell Cancer Institute participated in semi-structured qualitative interviews to explore their experiences and perspectives on RSM benefits and limitations.

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Introduction: Remote symptom monitoring (RSM) allows patients to electronically self-report symptoms to their healthcare team for individual management. Clinical trials have demonstrated overarching benefits; however, little is known regarding patient-perceived benefits and limitations of RSM programs used during patient care.

Methods: This prospective qualitative study from December 2021 to May 2023 included patients with cancer participating in standard-of-care RSM at the University of Alabama at Birmingham (UAB) in Birmingham, AL, and the Univeristy of South Alabama (USA) Health Mitchell Cancer Institute (MCI) in Mobile, AL.

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Background: We derived meaningful individual-level change thresholds for worsening in selected patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE®) items and their composite scores.

Methods: We used two data sources, the PRO-TECT trial (Alliance AFT-39) that collected PRO-CTCAE data from adults with advanced cancer at 26 United States (U.S.

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Introduction: Thoracic surgery is a mainstay of therapy for lung cancer and other chronic pulmonary conditions, but recovery is often complicated. Digital health systems can facilitate remote postoperative symptom management yet obstacles persist in their routine clinical adoption. This study aimed to identify patient-perceived barriers and facilitators to using an electronic patient-reported outcome (ePRO) monitoring platform specially designed to detect complications from thoracic surgery postdischarge.

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Background: Remote patient monitoring (RPM) of symptoms using electronic patient reported outcomes (ePROs) has been shown to reduce symptom burden and hospitalizations, increase dose intensity and improve quality of life of patients during systemic therapy being recommended by international guidelines in routine oncology practice. However, implementation in routine care has been slow and faces several challenges. In this study we report on the real-world multi-center implementation of a RPM pathway encompassing weekly patient symptom ePRO reporting with electronic alert notifications triggered to providers for severe or worsening symptoms.

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Background/aims: The Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) was developed to capture symptomatic adverse events from the patient perspective. We aim to describe statistical properties of PRO-CTCAE items and summary scores and to provide evidence for recommendations regarding PRO-CTCAE administration and reporting.

Methods: Using data from the PRO-CTCAE validation study (NCT02158637), prevalence, means, and standard deviations of PRO-CTCAE items, composite scores, and mean and maximum scores across attributes (frequency, severity, and/or interference) of symptomatic adverse events were calculated.

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Article Synopsis
  • Sunscreen with SPF 30 or higher is recommended for everyone, but traditional formulas often leave a white cast that doesn't suit darker skin tones.
  • A study conducted in Harlem during Spring 2023 identified 385 sunscreen products, revealing that 78.7% were traditional white sunscreens, with tinted options being limited and more expensive.
  • Tinted sunscreens, which are better for melanated skin, were found to be significantly less available and pricier compared to traditional ones, highlighting a need for improved access and affordability for effective sun protection.
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  • Early phase clinical trials focus on evaluating the safety and tolerability of new therapies, primarily using investigator and lab results rather than patient feedback.
  • A recent expert roundtable brought together 22 stakeholders to discuss the need for a universal patient-reported outcomes (PRO) model in early phase trials and how to effectively incorporate PROs to assess tolerability and guide treatment decisions.
  • The discussions yielded key recommendations and identified priority areas for further research on integrating patient feedback into early trials to improve safety and symptom management.
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  • The study looked into whether patients change their answers on surveys about their health when they know doctors will read them.
  • Researchers compared two groups of patients: one that knew their answers would be seen by doctors and another that didn't.
  • The results showed no big differences in answers between the two groups, suggesting it's okay for doctors to use these surveys to help understand patients' needs.
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  • This study evaluated patient engagement in remote symptom monitoring (RSM) programs for cancer, focusing on racial diversity among participants, as previous research showed low representation of racial minorities.
  • Out of 883 patients approached for RSM between May 2021 and May 2023, only 6% declined participation; however, Black patients were over three times more likely to decline compared to White patients, despite similar rates of being approached.
  • The findings suggest that Black patients and those from disadvantaged neighborhoods face challenges in engaging with RSM programs, indicating a need for further investigation to address barriers to equitable participation.
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  • Older adults with acute myeloid leukemia (AML) value their time spent at home compared to time spent in hospitals, influencing their treatment choices.
  • A study analyzed home time among patients aged 66 and older with AML, comparing those treated with anthracycline-based chemotherapy and hypomethylating agents (HMAs).
  • Results showed that while patients receiving HMAs had a shorter median survival, they enjoyed more days at home—averaging 222 days compared to 189 days for those on anthracyclines—highlighting the importance of home time in treatment decisions.
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  • FOLFIRI, a treatment for metastatic colorectal cancer, was tested using a pharmacogenomic strategy to tailor irinotecan doses based on UGT1A1 genotypes to see if it could improve progression-free survival (PFS).
  • In a study with 100 participants, results showed a median PFS of 12.5 months, which was shorter than expected, with variations in PFS based on genotype.
  • Although a tailored irinotecan strategy showed modest improvements in PFS for certain genotypes, it did not significantly change overall treatment outcomes and shouldn't replace current standard practices for first-line treatment.
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Purpose: Nutritional status is an established driver of cancer outcomes, but there is an insufficient workforce of registered dietitians to meet patient needs for nutritional counseling. Artificial intelligence (AI) and machine learning (ML) afford the opportunity to expand access to guideline-based nutritional support.

Methods: An AI-based nutrition assistant called Ina was developed on the basis of a learning data set of >100,000 expert-curated interventions, peer-reviewed literature, and clinical guidelines, and provides a conversational text message-based patient interface to guide dietary habits and answer questions.

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Introduction: Standard investigator-based adverse events (AE) assessment is via CTCAE for clinical trials. However, including the patient perspective through PRO (patient-reported outcomes) enhances clinicians' understanding of patient toxicity and fosters early detection of AEs. We assessed longitudinal integration of PRO-CTCAE within clinical workflow in a phase II trial.

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Purpose: Clinical benefits result from electronic patient-reported outcome (ePRO) systems that enable remote symptom monitoring. Although clinically useful, real-time alert notifications for severe or worsening symptoms can overburden nurses. Thus, we aimed to algorithmically identify likely non-urgent alerts that could be suppressed.

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Objective: To assess urologist attitudes toward clinical decision support (CDS) embedded into the electronic health record (EHR) and define design needs to facilitate implementation and impact. With recent advances in big data and artificial intelligence (AI), enthusiasm for personalized, data-driven tools to improve surgical decision-making has grown, but the impact of current tools remains limited.

Methods: A sequential explanatory mixed methods study from 2019 to 2020 was performed.

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Background: Treatment choices in hepatocellular carcinoma (HCC) involve consideration of tradeoffs between the benefits, toxicities, inconvenience, and costs. Stated preference elicitation methods have been used in the medical field to help evaluate complex treatment decision-making. The aim of this study was to conduct a scoping review to assess the evidence base for the use of preference elicitation tools or willingness to pay/willingness to accept methods for HCC treatment decision-making from both the patient and provider perspective.

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Article Synopsis
  • Regulatory agencies are promoting systematic collection of patient experience data, particularly patient-reported outcomes (PROs), in cancer trials to enhance regulatory decision-making.
  • There’s an increasing acknowledgment that understanding cancer treatment tolerability should involve the patients' perspectives, especially regarding side effects that may not be fully reported by clinicians.
  • Methodologies for evaluating patient-reported tolerability are being developed, but current methods remain largely descriptive, and inconsistencies in analyses and objectives of PROs present challenges for interpreting the results effectively.
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Health-related quality of life (HRQoL) is an important consideration in cancer clinical research, which can be substantially influenced by cancer treatment procedures and medications. The treatment landscape for early-stage (stage I-III) non-small cell lung cancer (NSCLC) is rapidly evolving. In this light, it is important to evaluate the most suitable instruments for HRQoL assessment and timing.

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Purpose: Postoperative education and symptom tracking are essential following cystectomy to reduce readmission rates and information overload. To address these issues, an internet-based tool was developed to provide education, alerts, and symptom tracking. We aimed to evaluate the tool's feasibility, acceptability, and impact on complication and readmission rates.

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