Computational and experimental pharmacology to decode the efficacy of L. against doxorubicin-induced organ toxicity in EAC-mediated solid tumor-induced mice.

Doxorubicin is extensively utilized chemotherapeutic drug, and it causes damage to the heart, liver, and kidneys through oxidative stress. L (cocoa) is reported to possess protective effects against several chemical-induced organ damages and also acts as an anticancer agent. The study aimed to determine whether the administration of cocoa bean extract reduces doxorubicin-induced organ damage in mice with Ehrlich ascites carcinoma (EAC) without compromising doxorubicin efficacy.

Effect of L. on the Efficacy and Toxicity of Doxorubicin in Mice Bearing Ehrlich Ascites Carcinoma.

Background And Objective: Doxorubicin is a widely used chemotherapeutic agent that causes oxidative stress leading to cardiotoxicity, hepatotoxicity, and nephrotoxicity. In contrast, L. has been recorded as an anticancer agent and found to be protective against multiple chemical-induced organ injuries, including heart, liver, and kidney injuries.

Network pharmacology and in vitro testing of Theobroma cacao extract's antioxidative activity and its effects on cancer cell survival.

Theobroma cacao L. is a commercially important food/beverage and is used as traditional medicine worldwide against a variety of ailments. In the present study, computational biology approaches were implemented to elucidate the possible role of cocoa in cancer therapy.

Potential ameliorative effect of (L.) on scopolamine-induced amnesia in rats: Restoration of cholinergic and antioxidant pathways.

Aim: The present study explored Cynodon dactylon hydro-ethanolic extract (CDE) effect on scopolamine-induced amnesic rats.

Materials And Methods: C. dactylon extract was subjected to antioxidant (DPPH and HO) and acetylcholinesterase enzyme tests by in vitro methods.

Integration of network and experimental pharmacology to decipher the antidiabetic action of Duranta repens L.

Objective: Duranta repens is reported to contain a wide array of secondary metabolites, including α-amylase and α-glucosidase inhibitors, and - has potent antioxidant activity. The present study evaluated the network pharmacology of D. repens (whole plant) with targets related to diabetes mellitus and assessed its outcome by evaluating the effects of the hydroalcoholic extract of D.

and anti-oxidant, cytotoxicity and biological activities of and .

Objective: To report anti-oxidant activity and cytotoxicity of hydroalcoholic extract of (bark) and (whole plant), and present the probable biological spectrum of major anti-oxidants from both plants.

Methods: The coarse powder of both plants was first extracted with 70% ethanol (maceration) followed by 99% ethanol (Soxhlet-extraction). Anti-oxidant activity of the extracts was evaluated using DPPH, HO, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), NO scavenging assay, total antioxidant capacity, cupric reducing antioxidant capacity (CUPRAC), and metal chelating assay.

Involvement of nitric oxide in 5-HT(3) receptor agonist-induced fluid accumulation in jejunum and colon of anesthetized rats.

Objectives: The aim of the present study was to investigate the involvement of nitric oxide in 5-HT(3) receptor agonist-induced fluid accumulation in jejunum and colon of anesthetized rats.

Materials And Methods: Fluid movement in jejunum and colon were determined simultaneously in the same rat, by modifying the Beubler method. Nomega-nitro-L-arginine (L-NNA, 20 mg/kg, s.

Elevation of systolic blood pressure in an animal model of olanzapine induced weight gain.

In the present study, we examined the effect of olanzapine on weight gain, systolic blood pressure and metabolic changes in rats. Female Sprague Dawley rats were treated with either vehicle or olanzapine (1 and 2 mg/kg i.p, twice daily) for 20 days.