Publications by authors named "Basak Koc"

Perceptions of death can greatly impact the ability to cope with grief, making it either easier or unbearable. Research on the importance of religion and spirituality in the field of oncology, particularly among parents who have lost a child to cancer, is still in its emerging stage. This study aimed to describe the religious coping strategies of Muslim mothers who lost their children to cancer.

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Childhood cancers, with leukemia at the forefront, comprise 97% acute leukemia and 3% chronic leukemia, with 75% of acute leukemias being of lymphoblastic origin. Over the past 50 years, survival rates have witnessed a remarkable increase, progressing from around 10% to achieving cure rates exceeding 90% in certain childhood ALL subgroups with the advent of combined therapies. Between 1999 and 2018, a total of 123 patients diagnosed with B-ALL were initially identified, but after applying exclusion criteria, 105 patients were included in the evaluation, who were treated with COG protocols at our center.

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Introduction: Radiosynovectomy (RS), which uses beta particle-emitting radiocolloids, has proven highly effective in significantly reducing the occurrence of haemarthroses and breaking the cycle of bleeding and synovitis. This study now presents the long-term outcomes of repeated RS in individuals with haemophilia.

Materials And Methods: Repeated RS was administered to 48 joints in 37 people with haemophilia (PwHs) diagnosed with chronic haemophilic synovitis.

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Background: Hemophilia B (HB), an X-linked recessive inherited bleeding disorder, exhibits a high prevalence among males.

Objectives: To present the first national cohort of persons with HB to define the demographics, clinical characteristics, and treatment patterns in Turkey.

Methods: This multicenter, retrospective study included 433 alive persons with HB registered in 35 centers between 1961 and 2018.

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Article Synopsis
  • * A study was conducted comparing 36 hemophilic patients and 37 non-hemophilic patients undergoing TKA, revealing that hemophilic patients used significantly more pain medication and had longer hospital stays.
  • * The findings suggest that pain management for hemophilia patients post-surgery should be tailored and proactive to better control acute pain.
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Objective: The purpose of this study was to describe factors affecting the place of death of children with cancer at the end of life.

Methods: The descriptive phenomenological approach was used. Eighteen mothers who lost their children to cancer participated in in-depth interviews.

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Background: Pineoblastomas (PB) are rare tumors of the central nervous system and are more common in children. There is no consensus about standard of care. The objective of this study is to analyze the outcome of children with PB.

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This multicenter cohort study aimed to determine the attitudes and expectations of persons with hemophilia of Generation Y (PwH-Y) toward hemophilia and its treatment comparatively with the opinions of their non-hemophiliac relatives. The study was representative regarding quota-control variables of hemophiliacs registered to the provincial representatives of the Hemophilia Society of Turkey in 4 geographic regions and Istanbul. Sixty-four PwH-Y (62 males) and their 56 first-degree relatives (17 males; Generation X/baby boomers) were interviewed face-to-face using mixed data collection method.

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Objective: This study aimed to observe the preventive effect of prophylactic treatment on joint health in people with hemophilia (PwH) and to investigate the importance of integration of ultrasonographic examination into clinical and radiological evaluation of the joints.

Materials And Methods: This national, multicenter, prospective, observational study included male patients aged ≥6 years with the diagnosis of moderate or severe hemophilia A or B from 8 centers across Turkey between January 2017 and March 2019. Patients were followed for 1 year with 5 visits (baseline and 3, 6, 9, and 12 month visits).

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Article Synopsis
  • The study evaluates the effectiveness of two assays (one-stage and chromogenic) for measuring factor VIII (FVIII) levels in patients with hemophilia A, which is caused by FVIII gene defects.
  • It involved analyzing 66 blood samples to determine the assays' precision, linearity, and comparability, revealing generally good results but significant bias in samples with FVIII activity below 40 IU.
  • Findings indicate the one-stage assay often yields higher FVIII levels compared to the chromogenic method, particularly for samples with lower concentrations, attributed to the chromogenic assay’s lower detection limit.
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Aim: Tolterodine is an anticholinergic drug used for the treatment of overactive bladder. We evaluated the effects of tolterodine on clinical symptoms and compared its efficacy with that of oxybutynin in terms of bladder capacity, bladder wall thickness, and post-void residual volume in children with overactive bladder.

Material And Methods: Twenty-six patients who were treated with tolterodine for overactive bladder (20 girls, mean age 8.

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Article Synopsis
  • The study analyzed 110 children diagnosed with acute lymphoblastic leukemia (ALL) to identify acute complications during their treatment and track survival rates.
  • The majority of patients had pre-B-cell ALL, with a notable occurrence of infections being the most common complication (88.5%), alongside other complications such as gastrointestinal and neurological issues.
  • The 5- and 10-year survival rates were both 85.9%, indicating that while childhood ALL is treatable, comprehensive care from a skilled medical team is essential due to potential acute complications.
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Introduction: People with haemophilia (PwH) with inhibitors have an increased risk of bleeding and early development of progressive arthropathy. Radiosynovectomy (RS) has been effective in dramatically reducing the frequency of haemarthroses. In the present study, the mid- and long-term results of the efficacy of RS in PwHs with inhibitors and prognostic factors that influence success and failure of RS were presented.

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Background: The risk of developing cancer increases with age and also adverse environmental conditions. The same holds true in the aging people with hemophilia (PwH). Furthermore, cancer is an important challenge for physicians working in multidisciplinary hemophilia care centers.

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Article Synopsis
  • * Out of 360 hemophilia A patients, 29 (8.05%) had inhibitors, and the study analyzed data from 15 patients who underwent low-dose ITI between 1999 and 2017.
  • * Results indicate that 33.3% of the patients had a complete response to low-dose ITI, while another 33.3% had partial responses, demonstrating that low-dose ITI could be a viable option for some patients despite challenges with higher-dose regimens.
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Lymphomas are solid tumors characterized by the malignant proliferation of lymphoid cells. Neurologic signs encountered in patients with Hodgkin's lymphoma can be due to the direct spread of tumor to the nervous system, secondary to chemotherapy or radiation, secondary to tumor mass compression, infectious causes and paraneoplastic syndromes. Paraneoplastic neurologic syndromes are rarely encountered in patients with Hodgkin's lymphoma and non-Hodgkin's lymphoma.

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Objective: Increased risk of unfavorable cardiovascular risk factors has been recognised in ageing patients with haemophilia (PwH), but needs further studies in younger patients. The purpose of this study was to assess obesity, hypertension (HT), metabolic variables, insulin resistance and metabolic syndrome in young PwH.

Methods: Forty-eight haemophilia A and B patients and 35 age and sex matched healthy controls were included in the study.

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Background: Burkitt leukemia (BL) with the precursor B-cell immunophenotype is a rarely reported condition. The prognosis of such patients is similar to that of classic BL. However, the combination of chromosomal translocations associated with bcl-2 and c-myc rearrangement has a poor prognosis.

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This is the report of a 2-year-old boy who presented with fever, cytopenia, and splenomegaly. The patient was diagnosed with hemophagocytic lymphohistiocytosis (HLH) and treated with HLH-2004 protocol. Repeated bone marrow aspiration showed amastigotes on follow-up.

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Background: The current study aimed at investigating the latent dimensional structure of sleep quality as indexed by the seven components of the Pittsburgh Sleep Quality Index (PSQI), as well as latent covariance structure between sleep quality, circadian preferences and depressive symptoms.

Methods: Two hundred twenty-five patients with major depressive disorder (MDD), with an average age of 29.92 ± 10.

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Individuals who differ markedly by sleep chronotype, i.e., morning-type or evening-type also differ on a number of psychological, behavioral, and biological variables.

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Article Synopsis
  • Bilateral congenital cystic adrenal neuroblastoma (NB) with cystic liver metastasis is an extremely rare condition, with only a handful of cases documented in existing literature.
  • The case presented involves a newborn with this specific type of NB, highlighting its rarity and complexity.
  • The discussion includes notable imaging features that help in identifying cystic neuroblastoma.
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