Publications by authors named "Basak Corak"
Article Synopsis
- Macrophages are diverse cells that inhabit all body tissues, with specific types residing in organs and additional subtypes recruited during injury.
- A specific population of recruited macrophages, marked by certain gene expressions, has been linked to fibrosis in various injury and cancer models.
- Blocking Notch2 increases these macrophages in the lungs, but evidence suggests they actually help reduce fibrosis rather than cause it, highlighting their potential protective role during lung injuries.
Antioxidant systems maintain cellular redox (oxidation-reduction) homeostasis. In contrast with other key redox pathways, such as the thioredoxin system, glutathione, and NF-E2-related factor 2 (Nrf2), little is known about the function of the redox-sensitive organelle "peroxisome" in immune cells. In this study, we show that the absence of peroxisomes in conditional -deficient mice strikingly results in impaired homeostatic maintenance of innate-like B cells, namely, B1 and marginal zone B cells, which translates into a defective Ab response to Surprisingly, however, follicular B2 cell development, homeostatic maintenance, germinal center reactions, Ab production, class switching, and B cell memory formation were unaffected in -deficient animals.
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