Publications by authors named "Basak Buse Karakuzulu"
Comput Biol Chem
August 2022
Article Synopsis
- * This study uses molecular dynamics simulations to analyze the interactions and binding affinities of PI3K inhibitors with specific PIK3CA hotspot mutations, revealing that alpelisib binds well, while inavolisib shows greater affinity for certain mutations.
- * The research highlights that specific mutations (like E542K) can drastically impair inhibitor interactions and affect the binding of natural ligands like ATP, which could influence the understanding of cancer mechanisms and aid in personalized medicine approaches.
