Drug-drug interaction checking assisted by clinical decision support: a return on investment analysis.

Background: Drug-drug interactions (DDIs) are very prevalent in hospitalized patients.

Objectives: To determine the number of DDI alerts, time saved, and time invested after suppressing clinically irrelevant alerts and adding clinical-decision support to relevant alerts.

Materials And Methods: The most frequently occurring DDIs were evaluated for clinical relevance by a multidisciplinary expert panel.