Publications by authors named "Bas Mathot"
Complications like acute cellular rejection (ACR) and infection are known risk factors for the development of chronic lung allograft dysfunction, impacting long-term patient and graft survival after lung transplantation (LTx). Differentiating between complications remains challenging and time-sensitive, highlighting the need for accurate and rapid diagnostic modalities. We assessed the ability of exhaled breath analysis using an electronic nose (eNose) to distinguish between ACR, infection, and mechanical complications in LTx recipients (LTR) presenting with suspected complications.
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- A study was conducted to compare two strategies for diagnosing interstitial lung disease (ILD): a step-up approach using transbronchial cryobiopsy followed by surgical lung biopsy (SLB) if needed, versus starting with immediate SLB.
- The COLD study included 55 patients across six hospitals in the Netherlands and measured outcomes like unexpected chest tube drainage, diagnostic yield, and adverse events over a 12-week follow-up.
- Findings showed that 11% of patients in the step-up group required unexpected chest tube drainage, indicating varying risks and benefits between the two biopsy methods.
Background: Bacterial colonization (BC) of the lower airways is common in lung transplant recipients (LTRs) and increases the risk of chronic lung allograft dysfunction. Diagnosis often requires bronchoscopy. Exhaled breath analysis using electronic nose (eNose) technology may noninvasively detect BC in LTRs.
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- Close monitoring of immunosuppressant levels after lung transplantation is crucial to avoid long-term complications, and therapeutic drug monitoring (TDM) is currently the method used for this.
- The study explored the use of a novel electronic nose (eNose) technology to assess Tacrolimus levels in lung transplant recipients through non-invasive breathprints, measuring correlations and diagnostic ability.
- Results showed a weak correlation between eNose measurements and Tacrolimus levels, with categorization accuracy ranging from 45%-69%, indicating that eNose technology is currently not reliable enough for TDM in this context.
Diagnostic performance of electronic nose technology in chronic lung allograft dysfunction.
J Heart Lung Transplant
February 2023
Background: There is a need for reliable biomarkers for the diagnosis of chronic lung allograft dysfunction (CLAD). In this light, we investigated the diagnostic value of exhaled breath analysis using an electronic nose (eNose) for CLAD, CLAD phenotype, and CLAD stage in lung transplant recipients (LTR).
Methods: We performed eNose measurements in LTR with and without CLAD, visiting the outpatient clinic.
Background: Evaluating and bridging patients to lung transplantation (LTx) on the intensive care unit (ICU) remains controversial, especially without a previous waitlist status. Long term outcome data after LTx from ICU remains scarce. We compared long-term survival and development of chronic lung allograft dysfunction (CLAD) in elective and LTx from ICU, with or without previous waitlist status.
View Article and Find Full Text PDFHome spirometry after lung transplantation is common practice, to monitor graft function. However, there is little experience with online home monitoring applications with direct data transfer to the hospital. We evaluated the feasibility and patient experiences with a new online home monitoring application, integrated with a Bluetooth-enabled spirometer and real-time data transfer.
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