COVID 19 and the risk of gastro-intestinal perforation: A case series and literature review.

Background: COVID19 is a viral disease with pneumonia as its most common presentation. Many presentations and complications have been reported, but gastro-intestinal perforation has not received much attention.

Methods: three cases from our hospital are presented, and the current literature was reviewed.

[A man with a skin lesion on the big toe].

We present a 48-year-old man who had developed a skin lesion on his big toe. In 2 years' time, the lesion had evolved from melanonychia striata to an erratic, erosive, granulomatous plaque of approximately 3,0 x 3,0 cm. Histopathological examination of 2 skin biopsies revealed a nodular melanoma.

Impact of the number of histologically examined lymph nodes on prognosis in colon cancer: a population-based study in the Netherlands.

Purpose: The impact of the reported number of lymph nodes at pathologic examination of colon specimens on survival was studied.

Methods: The data of 2,281 patients with localized colon cancer were retrospectively reviewed. The effect of tumor characteristics and surgical and pathologic factors on the number of lymph nodes and examined lymph node numbers on nodal status and survival were analyzed.

Right atrial overdrive pacing for prevention of symptomatic refractory atrial fibrillation.

Aims: Our aim was to investigate whether right atrial overdrive pacing is effective for the prevention of atrial fibrillation (AF) in patients without bradyarrhythmias.

Methods And Results: Patients with symptomatic paroxysmal or persistent AF refractory to at least two Class I or III antiarrhythmic drugs and without bradyarrhythmias were included. Successful therapy was defined as the combination of (a) a reduction of AF burden with or without AAD use >75%, (b) total AF burden < or =5% per year, and (c) less than one electrical cardioversion per year.