Publications by authors named "Bas Cj Majoor"
Fibrous dysplasia (FD) is a rare bone disorder caused by mutations of the GNAS gene, which are also identified in malignancies. We explored the potential relationship between breast cancer and fibrous dysplasia in two fibrous dysplasia cohorts from the Netherlands and the United States. Data on fibrous dysplasia and breast cancer diagnosis were retrieved from hospital records of 134 (Netherlands) and 121 (US) female patients.
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- - McCune-Albright syndrome (MAS) is a rare bone disorder that features fibrous dysplasia (FD), hormonal issues, and café-au-lait skin spots; patients with MAS often have a more severe form of the disease compared to those with polyostotic fibrous dysplasia (PFD).
- - A study assessed the outcomes of long-term bisphosphonate therapy in 11 MAS patients and 30 PFD patients, revealing that while many PFD patients responded well, only a small number of MAS patients showed significant improvement due to their higher disease severity and complications like precocious puberty and fractures.
- - The findings indicated that factors such as skeletal disease burden and specific biochemical markers (like FGF-23 and alkaline