Protocolized Versus Nonprotocolized Weaning to Reduce the Duration of Invasive Mechanical Weaning in Neonates: A Systematic Review of All Types of Studies.

Mechanical ventilation is one of the most commonly used treatments in neonatology. Prolonged mechanical ventilation is associated with deleterious outcomes. To reduce the ventilation duration, weaning protocols have been developed to achieve extubation in adult and pediatric care in a safe and uniform manner.

Ceramides in tracheal aspirates of preterm infants: Marker for bronchopulmonary dysplasia.

Background: In an experimental mouse model we showed that ceramides play a role in the pathogenesis of bronchopulmonary dysplasia (BPD) and are a potential target for therapeutic intervention. We investigated whether ceramides are detectable in tracheal aspirates (TAs) of preterm infants and differ between infants with or without BPD.

Methods: Infants born ≤ 32 weeks of gestational age in need of mechanical ventilation in the first week of life were included.

Protocolized versus non-protocolized weaning for reducing the duration of invasive mechanical ventilation in newborn infants.

Background: Mechanical ventilation is a life-saving intervention for critically ill newborn infants with respiratory failure admitted to a neonatal intensive care unit (NICU). Ventilating newborn infants can be challenging due to small tidal volumes, high breathing frequencies, and the use of uncuffed endotracheal tubes. Mechanical ventilation has several short-term, as well as long-term complications.

Neurally adjusted ventilatory assist: assessing the comfort and feasibility of use in neonates and children.

Aim: To evaluate the practical feasibility for nurses working with neurally adjusted ventilatory assist (NAVA) and assess patient comfort and safety when NAVA is initiated.

Background: NAVA is a relatively new mode of ventilation. Its application in neonates and children has been widely documented.