[Prevalence and risk factors of constipation in the adult population of Moscow (according to population-based study MUSA)].

Unlabelled: Aim was assessment prevalence of chronic constipation (CC) in adult Moscow population and associated prevalence/risk factors.

Material & Methods: Data was collected from 1189 randomly selected subjects older than 18 y. o.

[Prevalence of diverticulosis and colon tumors among adult population of Moscow with constipation and symptoms of anxiety (according to population-based study MUSA)].

Unlabelled: Aim was to assess the diagnostic value of the alarm symptoms (AS's) in subjects with constipation based on prospective examination of adult population.

Material & Methods: Data was collected from 1189 randomly selected subjects older than 18 y.o.

[The damaging role of endogenous nitric oxide in the development of the experimental DSS-induced colitis in rats].

An experimental study on rats to determine the role of inducible NO production in the pathogenesis of inflammation of the mucous membrane of the colon. The introduction of DSS induces the formation of lesions of the colon mucosa of different severity, which is accompanied by increased synthesis of NO and the stable metabolite of NO - citrulline. Inhibition of NO-synthase reduces the release of NO and the formation of lesions of the colon.

[Lower extremity deep vein thrombosis associated with gluten-sensitivity celiac disease].

The paper describes a clinical case of gluten-sensitivity celiac disease (GSCD) and recurrent lower extremity vein thrombosis in a female patient. According to the data available in the literature, GSCD is associated with increased risk for thrombosis. Hyperhomocysteinemia and protein S, folates, and vitamin B, 2 deficiencies may be responsible for thrombophilia in GSCD.

[Cytomegalovirus infection in patients with ulcerative colitis].

Aim: Adjusting therapy of patients with ulcerative colitis (UC) regarding their cytomegalovirus (CMV)--status.

Materials And Methods: 40 patients were included, mean age--44.3 +/- 3.

[4th Congress of ECCO (5-7 February 2009, Hamburg (Germany). (The European Crohn's and Colitis Organization)--Inflammatory bowel diseases 2009)].

In February 5-7, 2009 in Hamburg (Germany) 4th Congress of ECCO (the European Crohn's and Colitis Organization) took place. More than 2000 specialists in IBD from the European and the other countries participated at the Congress. The theme of the meeting was "The Unmet Need in inflammatory Bowel Disease".

[Adalimumab therapy in Crohn's disdease].

In spite of using biologic agents for treatment of Crohn's disease (CD), the problem of therapy of CD hasn't been resolved yet. As was shown, approximately 60% patients can't continue treatment with Infliximab because of its primary non-response or secondary loss of response or intolerance. The fully-human monoclonal antibody against tumor necrosis factor-alpha (TNF-alpha), Adalimumab, was significantly effective in randomized placebo-controlled studies for induction remission and for maintaining therapy of CD as well.

[Role of nitric oxide (NO) in the etiopathogenesis of certain alimentary diseases].

Nitric oxide is one of essential regulators of the physiological functions of the gastrointestinal tract including vascular tone, transfer of nerve impulses, protection of mucous coats, motor activity and secretion. The review of literature presents data on sources of nitric oxide, its molecular and cellular interaction, role in the genesis of different diseases of the gastrointestinal tract. The experimental and clinical material provides grounds for approaches to the regulation of this signaling pathway with the help of nitric oxide donors, activators and inhibitors of its formation, arginine, antioxidants, phosphodiesterase and guanylate cyclase inhibitors.