Publications by authors named "Baruc Campos Campos"
Article Synopsis
- The study explores how dopamine D1 and D2 receptor (DR-DR) heteromers can influence the effects of selective dopamine ligands, suggesting their relevance as drug development targets.
- Researchers demonstrated that three similar dopamine ligands (PG01042, PG01037, and VK4-116) have distinct effects based on DR-DR heteromerization, showing varying roles in signaling.
- The findings indicate that GPCR heteromers should be considered key targets for drug development, especially for conditions like L-DOPA-induced dyskinesia in Parkinson's disease, rather than focusing solely on individual GPCR components.
Dopamine D R are widely expressed in basal ganglia where interact with D R. D R potentiate cAMP accumulation and GABA release stimulated by D R in striatonigral neurons through "atypical" signaling. During dopaminergic denervation, D R signaling changes to a "typical" in which antagonizes the effects of D R, the mechanisms of this switching are unknown.
View Article and Find Full Text PDFInhalant abuse constitutes an important public health problem in Mexico that is more prevalent among children and adolescents. Commercial products that are abused are complex mixtures of solvents containing mainly toluene, in association with other solvents like benzene and xylene. Epidemiological evidence indicates that chronic solvent abuse exposure can cause loss of appetite among other unwanted effects.
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