Effect of Rho-associated kinase inhibitor on human corneal endothelial cell apoptosis.

Purpose: To evaluate whether exposure to Rho-associated protein kinase (ROCK) inhibitor will promote human-cultured corneal endothelial cells (CECs) survival in a commercial storage medium.

Setting: Edith Wolfson Medical Center, Holon, and Sheba Medical Center, Tel Hashomer, Israel.

Design: Experimental study.

Prophylactic exposure of human corneal endothelial cells to Rho-associated kinase inhibitor reduced apoptosis rate after phacoemulsification: Ex vivo study.

Purpose: To evaluate whether prophylactic exposure of corneal endothelial cells (CECs) to a selective Rho-associated kinase (ROCK) inhibitor will inhibit CEC apoptosis after phacoemulsification.

Setting: Laboratory evaluations at the Edith Wolfson Medical Center, Holon, Israel and the Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel and the Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.

Design: Experimental study.

Retinal layers thickness changes following epiretinal membrane surgery.

PurposeTo evaluate the time course of changes in the thickness of retinal layers after epiretinal membrane (ERM) removal surgery.MethodsA retrospective cohort study of patients following surgery for idiopathic ERM. We used new specialized image analysis software to create a thickness map of each retinal layer and analyzed changes during one year follow-up.

Corneal Staining and Hot Black Tea Compresses.

Background: Warm compresses are widely touted as an effective treatment for ocular surface disorders. Black tea compresses are a common household remedy, although there is no evidence in the medical literature proving their effect and their use may lead to harmful side effects.

Objectives: To describe a case in which the application of black tea to an eye with a corneal epithelial defect led to anterior stromal discoloration; evaluate the prevalence of hot tea compress use; and analyze, in vitro, the discoloring effect of tea compresses on a model of a porcine eye.

Intraocular pressure measurement after DSAEK by iCare, Goldmann applanation and dynamic contour tonometry: A comparative study.

Purpose: Corneal thickness inevitably increases following Descemet's stripping automated endothelial keratoplasty (DSAEK), owing to the addition of a donor graft. The current study compares different devices in assessing post-DSAEK intraocular pressure (IOP).

Methods: We compared IOP values measured by the Goldmann tonometry (GAT), iCare rebound tonometry (iCare) and Pascal dynamic contour tonometry (PDCT) in eyes following DSAEK.

TOPICAL APRACLONIDINE REDUCES PAIN AFTER INTRAVITREAL INJECTIONS: A Double-Blind Randomized Controlled Trial.

Purpose: To evaluate the efficacy of topical apraclonidine in reducing pain and subconjunctival hemorrhage (SCH) after intravitreal injections (IViT).

Methods: A prospective, randomized, double-blinded study. Thirty-nine patients were examined twice, at each monthly IViT of 1.

Photoreceptor Integrity Predicts Response to Anti-VEGF Treatment.

Purpose: Assessing changes in foveal photoreceptor microstructure (FPM) following intravitreal anti-VEGF treatment may serve as a prognostic marker in patients with macular edema (ME).

Methods: Sixteen eyes belonging to newly diagnosed patients with ME were included in this prospective longitudinal study. FPM integrity was evaluated at baseline and at the end of a series of anti-VEGF injections.

Predicting cataract surgery time based on preoperative risk assessment.

Purpose: Operating room (OR) time is an expensive resource that should be optimized to reduce costs. Individualpreoperative risk parameters (PORS) assessment may aid in predicting cataract surgery time.

Methods: Dedicated software was developed and known risk factors for cataract surgery were integrated into it.

Blood-Flow Velocity in Glaucoma Patients Measured with the Retinal Function Imager.

Purpose: Circulatory abnormalities in the retina, optic nerve and choroid have been detected by various technologies in glaucoma patients. However, there is no clear understanding of the role of blood flow in glaucoma. The purpose of this study was to compare retinal blood-flow velocities using the retinal function imager (RFI) between glaucoma and healthy subjects.

Quantification of metamorphopsia using the MacuFlow test before and after vitreoretinal surgery.

Background And Objective: This pilot study evaluated the clinical utility of the MacuFlow software in measuring metamorphopsia prior to and following surgery in patients with vitreoretinal diseases.

Patients And Methods: Four patients with vitreoretinal disorders causing metamorphopsia were included in this pilot study. Visual acuity (VA), optical coherence tomography and MacuFlow scores were recorded prior to and following surgical intervention.

Quantifying metamorphopsia in patients with diabetic macular oedema and other macular abnormalities.

Purpose: To quantify subjective visual metamorphopsia in newly diagnosed patients suffering from diabetic macular oedema (DME) and other macular abnormalities and to evaluate anti-VEGF treatment effect.

Methods: Patients with DME, subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) or retinal venous occlusion (RVO) were recruited. Metamorphopsia score (Mscore) was calculated using M-Charts at baseline and at the end of a series of anti-VEGF injections.

Compliance with eye care in glaucoma patients with comorbid depression.

Background: Comorbid depression may play an important role in non-compliance with medical treatment among patients with chronic illnesses. Glaucoma is a potentially blinding chronic disease requiring life-long commitment to medical therapy. Failure to adhere to anti-glaucoma treatment may lead to disease progression and visual loss.

High-resolution wide-field imaging of perfused capillaries without the use of contrast agent.

Purpose: Assessment of capillary abnormalities facilitates early diagnosis, treatment, and follow-up of common retinal pathologies. Injected contrast agents like fluorescein are widely used to image retinal capillaries, but this highly effective procedure has a few disadvantages, such as untoward side effects, inconvenience of injection, and brevity of the time window for clear visualization. The retinal function imager (RFI) is a tool for monitoring retinal functions, such as blood velocity and oximetry, based on intrinsic signals.

Inter-device variability of the Stratus optical coherence tomography.

Purpose: To assess inter-device measurement variability with the Stratus optical coherence tomography (OCT).

Design: Evaluation of diagnostic test technology.

Methods: Eight eyes of eight healthy subjects were examined with four different Stratus machines in four medical centers during a period of five hours using fast retinal nerve fiber layer (RNFL) and fast macula protocols.

Season of birth, natural light, and myopia.

Purpose: To investigate the possible roles of season of birth and perinatal duration of daylight hours (photoperiod) in the development of myopia.

Design: Retrospective, population-based, epidemiological study.

Participants: A total of 276 911 adolescents (157 663 male, 119 248 female) 16 to 22 years old.

Modified sutureless sclerotomies for pars plana vitrectomy.

Purpose: To describe a modified technique for performing sutureless sclerotomies for pars plana vitrectomy and to examine its efficacy and safety.

Design: Retrospective, interventional case series.

Methods: Self-sealing sclerotomies were created in 35 consecutive cases by oblique penetration of the sclera with a 19G MVR blade.

Inadvertent intravitreal gentamicin injection.

Purpose: To describe the management and consequences of an accidental injection of gentamicin in the vitreous.

Methods: A retinal detachment developed in a 70-year-old male. During a vitrectomy operation, gentamicin (20mg) was accidentally injected in to the eye.

Minimal astigmatism after sutureless planned extracapsular cataract extraction.

Purpose: To evaluate astigmatism after mini-nuc extracapsular cataract extraction (ECCE) in which a chevron incision is enlarged to 6.0 to 7.0 mm for easier nucleus removal and to compare the results with those using a 5.

Pulsatile ocular blood flow in diabetic retinopathy.

Purpose: To assess circulatory properties of eyes with progressive stages of diabetic retinopathy.

Methods: The intraocular pressure, pulse amplitude (PA) and pulsatile ocular blood flow (POBF) were measured with a pneumatonometer (OBF Labs UK Ltd). The eyes were grouped: (a) normal control, n = 26, (b) diabetes with no observable diabetic retinopathy (NDR), n = 18, (c) mild to moderate non-proliferative diabetic retinopathy (NPDR), n = 20, and (d) very severe pre-proliferative and proliferative diabetic retinopathy (PPDR/PDR), n = 12.

Total internal reflection of laser light in eyes filled with silicone oil.

Background And Objectives: This is the first report of clinical settings in which total internal reflection of laser light in eyes filled with silicone oil was observed. The authors analyze this phenomenon and outline the potential hazards it may present to patient, surgeon, and operating room personnel.

Materials And Methods: The authors observed significant reflection of laser light off the silicone-water interface both intraoperatively and in the clinic.

Managing inferior zonule tears during manual extracapsular cataract extraction.

We describe a new technique for safely concluding manual extracapsular cataract extraction in the presence of a rupture of the interior zonules. A lens glide is inserted in the anterior chamber. The tip of the glide is placed in the inferior part of the capsular bag, pushing it toward the ciliary sulcus at 6 o'clock.