Publications by authors named "Bartosz Witczak"
Article Synopsis
- - The study investigates the relationship between the NOS2 gene polymorphism rs2297518 and colorectal cancer (CRC), focusing on how it may differ between right-sided and left-sided colon cancers as well as rectal cancers.
- - Researchers analyzed 199 CRC patients and 120 controls using a TaqMan genotyping assay to assess the frequency of the minor allele A in the NOS2 genotype across various tumor locations.
- - Findings indicate that the minor allele A is significantly more common in right-sided CRC compared to left-sided and rectal cancers, suggesting that this genetic variant plays a role in the tumor's localization and development.
Association between Glutathione S-Transferases Gene Variants and COVID-19 Severity in Previously Vaccinated and Unvaccinated Polish Patients with Confirmed SARS-CoV-2 Infection.
Int J Environ Res Public Health
February 2023
As the outcome of COVID-19 is associated with oxidative stress, it is highly probable that polymorphisms of genes related to oxidative stress were associated with susceptibility and severity of COVID-19. The aim of the study was to assess the association of glutathione S-transferases (GSTs) gene polymorphisms with COVID-19 severity in previously vaccinated and unvaccinated Polish patients with confirmed SARS-CoV-2 infection. A total of 92 not vaccinated and 84 vaccinated patients hospitalized due to COVID-19 were included.
View Article and Find Full Text PDFGlutathione S-Transferase P1 Genetic Variant's Influence on the HbA1c Level in Type Two Diabetic Patients.
Int J Environ Res Public Health
January 2023
GST (glutathione S-transferases) are capable of influencing glucose homeostasis, probably through regulation of the response to oxidant stress. The aim of our study was to investigate the relationship between GSTP1 gene polymorphism and glycated hemoglobin (HbA1c) levels in type two diabetic (T2D) patients. A total of 307 T2D patients were included.
View Article and Find Full Text PDFGlutathione S-transferases gene polymorphism influence on the age of diabetes type 2 onset.
BMJ Open Diabetes Res Care
November 2020
Introduction: Type 2 diabetes (T2D) is a multifactorial disease affecting mostly adults older than 40 years. The aim of the study was to examine gene polymorphism influence on the risk of T2D, especially in young adults.
Research Design And Methods: 200 diabetic patients and 221 healthy controls participated in this study.