Misinformation, Fears and Adherence to Preventive Measures during the Early Phase of COVID-19 Pandemic: A Cross-Sectional Study in Poland.

The response to the pandemic requires access to accurate information and public understanding and adherence to preventive measures. This online cross-sectional study of adult Poles ( = 1337) assessed the frequency of COVID-19 preventive behaviors, fears related to the COVID-19 pandemic, and beliefs in COVID-19-related conspiracy theories during the early phase of the COVID-19 pandemic when the nationwide lockdown was imposed (April 2020). As shown, 22% of surveyed admitted not to wash their hands frequently, while 12% did not use disinfectants.

The Productivity of Medical Publication on COVID-19 in the First Half of 2020: A Retrospective Analysis of Articles Available in PubMed.

Background The control of the coronavirus disease 2019 (COVID-19) pandemic depends on the profound investigation of the virus biology and its consequences. We aimed to analyze the COVID-19 research productivity of authors representing different countries and associations between the number of articles and COVID-19 spread. Methods We retrieved all articles on COVID-19 indexed in PubMed between 31 December 2019 and 30 June 2020.

Mutant CAG Repeats Effectively Targeted by RNA Interference in SCA7 Cells.

Spinocerebellar ataxia type 7 (SCA7) is a human neurodegenerative polyglutamine (polyQ) disease caused by a CAG repeat expansion in the open reading frame of the gene. The allele-selective silencing of mutant transcripts using a repeat-targeting strategy has previously been used for several polyQ diseases. Herein, we demonstrate that the selective targeting of a repeat tract in a mutant transcript by RNA interference is a feasible approach and results in an efficient decrease of mutant ataxin-7 protein in patient-derived cells.