Publications by authors named "Bartosz Jaroszewski"
Natural origin products are regarded as promising for the development of new therapeutic therapies with improved effectiveness, biocompatibility, reduced side effects, and low cost of production. Betulin (BE) is very promising due to its wide range of pharmacological activities, including its anticancer, antioxidant, and antimicrobial properties. However, despite advancements in the use of triterpenes for clinical purposes, there are still some obstacles that hinder their full potential, such as their hydrophobicity, low solubility, and poor bioavailability.
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- Human β-defensin 3 (HBD-3) is a small peptide that has antimicrobial properties and helps regulate the immune system, interacting with various receptors in the body.* -
- The study focuses on improving the synthesis of HBD-3 through a refined solid-phase method and using specific techniques to reduce issues like chain aggregation.* -
- The researchers also explored an alternative method that substitutes a disulfide bond with a diselenide bond, enhancing the peptide's folding, which could lead to better understanding and applications of HBD-3 in medicine.*