Sporadic Angiomyolipomas Growth Kinetics While on Everolimus: Results of a Phase II Trial.

Purpose: Everolimus decreases tumor volume of renal angiomyolipomas in patients with tuberous sclerosis. No prospective data are available regarding the effect of everolimus on the growth kinetics in patients with sporadic angiomyolipomas. We sought to determine the safety and efficacy of everolimus in the volumetric reduction of sporadic angiomyolipomas.

Neoadjuvant chemoradiation and duration of chemotherapy before surgical resection for pancreatic cancer: does time interval between radiotherapy and surgery matter?

Background: Neoadjuvant chemoradiation and chemotherapy provided for borderline or locally advanced, potentially resectable pancreatic adenocarcinoma improves resectability rates. Response to therapy is also an important prognostic factor. There are no data in the literature regarding optimal time interval or duration of chemotherapy after chemoradiation before surgery, and pathologic response rates.

False-positive scalp activity in 131I imaging associated with hair coloring.

A patient with metastatic papillary thyroid carcinoma (after surgical resection of tumor and positive lymph nodes) undergoing thyroid ablation therapy with (131)I is described. Whole-body scintigraphy was performed 1 wk after ablation therapy to evaluate the presence of residual disease. The whole-body images demonstrated an artifact caused by tracer accumulation in the patient's scalp related to recent hair coloring.

Knee articular cartilage damage in osteoarthritis: analysis of MR image biomarker reproducibility in ACRIN-PA 4001 multicenter trial.

Purpose: To prospectively determine the reproducibility of quantitative magnetic resonance (MR) imaging biomarkers of the morphology and composition (spin lattice relaxation time in rotating frame [T1-ρ], T2) of knee cartilage in a multicenter multivendor trial involving patients with osteoarthritis (OA) and asymptomatic control subjects.

Materials And Methods: This study was HIPAA compliant and approved by the institutional review committees of the participating sites, with written informed consent obtained from all participants. Fifty subjects from five sites who were deemed to have normal knee joints (n = 18), mild OA (n = 16), or moderate OA (n = 16) on the basis of Kellgren-Lawrence scores were enrolled.

Defining venous involvement in borderline resectable pancreatic cancer.

Background: Pancreatic adenocarcinoma impinging the portal and/or superior mesenteric vein (PV-SMV) is classified as borderline resectable, and preoperative chemoradiation is recommended to increase the margin-negative resection rate. There is no consensus about what degree of venous impingement constitutes borderline resectability.

Methods: All patients undergoing potentially curative pancreatectomy for pancreatic adenocarcinoma were reviewed.

Findings of intramediastinal gossypiboma with F-18 FDG PET in a melanoma patient.

FDG PET/CT scan was performed to evaluate recurrence in an asymptomatic 64-year-old man with a history of melanoma in the left posterior ear. PET/CT images showed an intense ring-shaped area of FDG activity in the posterior mediastinum in a large posterior mediastinal mass. However, further evaluation indicated that this activity was caused by an intramediastinal gossypiboma after coronary artery bypass graft surgery 4 years before the PET/CT scan.

Cranial nerve deficits in patients with metastatic prostate carcinoma: clinical features and treatment outcomes.

Background: Cranial nerve lesions due to metastases from prostate carcinoma to the skull base are an uncommon yet clinically significant finding.

Methods: The authors report the clinical features, treatment, and outcomes for 15 patients who presented with cranial nerve palsies complicating metastatic prostate carcinoma. Patient charts identified from a Fox Chase Cancer Center treatment data base were reviewed.

Radiographic assessment of airway tumors.

The initial imaging evaluation of a patient with a suspected tracheal abnormality is the chest radiograph, which is poor for detection of central airway lesions. Prior to the development of CT, planar tomography was performed to better evaluate the deep layers of the chest. Tomography is rarely performed today for chest imaging.