Lavender Essential Oil and Its Terpenic Components Negatively Affect Tumor Properties in a Cell Model of Glioblastoma.

Glioblastoma (GBM) is the most common and aggressive form of brain cancer in adults, characterized by extensive growth, a high recurrence rate, and resistance to treatment. Growing research interest is focusing on the biological roles of natural compounds due to their potential beneficial effects on health. Our research aimed to investigate the effects of lavender essential oil (LEO) on a GBM cell model.

Two FAM134B isoforms differentially regulate ER dynamics during myogenesis.

Endoplasmic reticulum (ER) plasticity and ER-phagy are intertwined processes essential for maintaining ER dynamics. We investigated the interplay between two isoforms of the ER-phagy receptor FAM134B in regulating ER remodeling in differentiating myoblasts. During myogenesis, the canonical FAM134B1 is degraded, while its isoform FAM134B2 is transcriptionally upregulated.

Improving manual dexterity using ergonomic wearable glove in patients with multiple sclerosis: A quasi-randomized clinical trial.

One main problem faced by people with multiple sclerosis (PwMS) is upper limb dysfunction, which can occur in the first decade of the disease and with the highest prevalence of disability in the progressive type of the disease. Then, PwMS may benefit from personalised and intensive treatment as provided by robotic devices. These innovative devices have increasingly been brought into the neurorehabilitation field, due to their ability to provide repetitive and task-oriented training.

Microbial Biocontrol Agents and Natural Products Act as Salt Stress Mitigators in L.

One of the major problems related to climate change is the increase in land area affected by higher salt concentrations and desertification. Finding economically and environmentally friendly sustainable solutions that effectively mitigate salt stress damage to plants is of great importance. In our work, some natural products and microbial biocontrol agents were evaluated for their long-term effectiveness in reducing salt stress in lettuce ( L.

Evaluating and extending speedup techniques for optimal crossing minimization in layered graph drawings.

A layered graph is an important category of graph in which every node is assigned to a layer, and layers are drawn as parallel or radial lines. They are commonly used to display temporal data or hierarchical graphs. Previous research has demonstrated that minimizing edge crossings is the most important criterion to consider when looking to improve the readability of such graphs.

Quality Metrics and Reordering Strategies for Revealing Patterns in BioFabric Visualizations.

Visualizing relational data is crucial for understanding complex connections between entities in social networks, political affiliations, or biological interactions. Well-known representations like node-link diagrams and adjacency matrices offer valuable insights, but their effectiveness relies on the ability to identify patterns in the underlying topological structure. Reordering strategies and layout algorithms play a vital role in the visualization process since the arrangement of nodes, edges, or cells influences the visibility of these patterns.

Illuminating the Landscape of Differential Privacy: An Interview Study on the Use of Visualization in Real-World Deployments.

As Differential Privacy (DP) transitions from theory to practice, visualization has surfaced as a catalyst in promoting acceptance and usage. Despite the potential of visualization tools to support differential privacy implementation, their development is limited by a lack of understanding of the overall deployment process, practitioner challenges, and the role of visual tools in real-world deployments. To narrow this gap, we interviewed 18 professionals from various backgrounds who regularly engage with differential privacy in their work.

Doom or Deliciousness: Challenges and Opportunities for Visualization in the Age of Generative Models.

Generative text-to-image models (as exemplified by DALL-E, MidJourney, and Stable Diffusion) have recently made enormous technological leaps, demonstrating impressive results in many graphical domains-from logo design to digital painting to photographic composition. However, the quality of these results has led to existential crises in some fields of art, leading to questions about the role of human agency in the production of meaning in a graphical context. Such issues are central to visualization, and while these generative models have yet to be widely applied in visualization, it seems only a matter of time until their integration is manifest.

Unraveling the Design Space of Immersive Analytics: A Systematic Review.

Immersive analytics has emerged as a promising research area, leveraging advances in immersive display technologies and techniques, such as virtual and augmented reality, to facilitate data exploration and decision-making. This paper presents a systematic literature review of 73 studies published between 2013-2022 on immersive analytics systems and visualizations, aiming to identify and categorize the primary dimensions influencing their design. We identified five key dimensions: Academic Theory and Contribution, Immersive Technology, Data, Spatial Presentation, and Visual Presentation.

AMBRA1 phosphorylation by CDK1 and PLK1 regulates mitotic spindle orientation.

AMBRA1 is a crucial factor for nervous system development, and its function has been mainly associated with autophagy. It has been also linked to cell proliferation control, through its ability to regulate c-Myc and D-type cyclins protein levels, thus regulating G1-S transition. However, it remains still unknown whether AMBRA1 is differentially regulated during the cell cycle, and if this pro-autophagy protein exerts a direct role in controlling mitosis too.

Bromodomain and Extraterminal Domain (BET) Protein Inhibition Hinders Glioblastoma Progression by Inducing Autophagy-Dependent Differentiation.

Glioblastoma multiforme (GBM) is the most common and aggressive type of malignant primary brain tumor, and it is characterized by a high recurrence incidence and poor prognosis due to the presence of a highly heterogeneous mass of stem cells with self-renewal capacity and stemness maintenance ability. In recent years, the epigenetic landscape of GBM has been explored and many epigenetic alterations have been investigated. Among the investigated epigenetic abnormalities, the bromodomain and extra-terminal domain (BET) chromatin readers have been found to be significantly overexpressed in GBM.

Regulation of Cell Plasticity by Bromodomain and Extraterminal Domain (BET) Proteins: A New Perspective in Glioblastoma Therapy.

BET proteins are a family of multifunctional epigenetic readers, mainly involved in transcriptional regulation through chromatin modelling. Transcriptome handling ability of BET proteins suggests a key role in the modulation of cell plasticity, both in fate decision and in lineage commitment during embryonic development and in pathogenic conditions, including cancerogenesis. Glioblastoma is the most aggressive form of glioma, characterized by a very poor prognosis despite the application of a multimodal therapy.

Lavender Essential Oil Modulates Hepatic Cholesterol Metabolism in HepG2 Cells.

Cholesterol is an essential lipid that guarantees several biological processes in eukaryotic cells. Its metabolism is regulated by a complex protein network that could be significantly influenced by numerous exogenous sources, such as essential oils (EOs). For instance, it has been speculated that monoterpenoid and sesquiterpenoid compounds contained in lavender essential oil (LEO) may exert important hypocholesterolemic activities.

The State of the Art in BGP Visualization Tools: A Mapping of Visualization Techniques to Cyberattack Types.

Internet routing is largely dependent on Border Gateway Protocol (BGP). However, BGP does not have any inherent authentication or integrity mechanisms that help make it secure. Effective security is challenging or infeasible to implement due to high costs, policy employment in these distributed systems, and unique routing behavior.

Special Issue "Tumors of the Nervous System: New Insights into Signaling, Genetics and Therapeutic Targeting".

This Special Issue focused on the current understanding of signaling pathways as well as genetic and epigenetic features involved in the pathogenesis of brain tumors and other nervous system tumors, with emphasis on the development of novel therapeutic approaches aimed at improving the current standard of care [...

STRATISFIMAL LAYOUT: A modular optimization model for laying out layered node-link network visualizations.

Node-link visualizations are a familiar and powerful tool for displaying the relationships in a network. The readability of these visualizations highly depends on the spatial layout used for the nodes. In this paper, we focus on computing layered layouts, in which nodes are aligned on a set of parallel axes to better expose hierarchical or sequential relationships.

Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis.

Neurotrophins constitute a family of growth factors initially characterized as predominant mediators of nervous system development, neuronal survival, regeneration and plasticity. Their biological activity is promoted by the binding of two different types of receptors, leading to the generation of multiple and variegated signaling cascades in the target cells. Increasing evidence indicates that neurotrophins are also emerging as crucial regulators of metabolic processes in both neuronal and non-neuronal cells.

Targeting RTK-PI3K-mTOR Axis in Gliomas: An Update.

Gliomas are the most common and challenging malignancies of the central nervous system (CNS), due to their infiltrative nature, tendency to recurrence, and poor response to treatments. Indeed, despite the advances in neurosurgical techniques and in radiation therapy, the modest effects of therapy are still challenging. Moreover, tumor recurrence is associated with the onset of therapy resistance; it is therefore critical to identify effective and well-tolerated pharmacological approaches capable of inducing durable responses in the appropriate patient groups.

Respiratory Manifestations in Systemic Lupus Erythematosus.

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by a wide spectrum of clinical manifestations. The respiratory system can be involved in up to 50-70% of patients and be the presenting manifestation of the disease in 4-5% of cases. Every part of the respiratory part can be involved, and the severity can vary from mild self-limiting to life threatening forms.

Sequence Braiding: Visual Overviews of Temporal Event Sequences and Attributes.

Temporal event sequence alignment has been used in many domains to visualize nuanced changes and interactions over time. Existing approaches align one or two sentinel events. Overview tasks require examining all alignments of interest using interaction and time or juxtaposition of many visualizations.

ProNGF/p75NTR Axis Drives Fiber Type Specification by Inducing the Fast-Glycolytic Phenotype in Mouse Skeletal Muscle Cells.

Despite its undisputable role in the homeostatic regulation of the nervous system, the nerve growth factor (NGF) also governs the relevant cellular processes in other tissues and organs. In this study, we aimed at assessing the expression and the putative involvement of NGF signaling in skeletal muscle physiology. To reach this objective, we employed satellite cell-derived myoblasts as an in vitro culture model.

Hepatitis E Virus and rheumatic diseases: what do rheumatologists need to know?

Background: Hepatitis E virus (HEV) represents the most common cause of acute hepatitis and jaundice in the world. About 2 million of infection cases occur each year in Europe, mainly as autochthonous anthropozoonosis, and HEV can be transmitted through undercooked pork meat. This infection has been linked to various extra-hepatic manifestations, while chronic infections with a rapid development of liver failure have been described in heavily immunosuppressed patients undergoing solid organ transplantations (SOTs), in patients with hematological diseases or with immunodeficiency virus infection.