Familial association of laryngeal, lung, stomach and early-onset breast cancer.

This study analyzes the incidence of different types of cancer among 2839 first-degree relatives of 760 consecutive, unselected laryngeal cancer patients, compared with the general population. A statistically significant excess was seen for other cancers of the larynx (SIR: 400), lung (SIR: 135) and stomach (SIR: 271), and early-onset breast cancer (SIR: 287). Familial laryngeal cancer may not be a single site-specific cancer syndrome.

Clinical and epidemiological features of familial laryngeal cancer in Poland.

Background: Laryngeal cancer has one of the worst recurrence rates for any malignancy, is known to be influenced by several environmental factors, and it is significantly more common in males than females. Familial clusterings of laryngeal cancer have been reported but no systematic evaluation of the clinical feature of the disease or an in-depth analysis of familial forms of the disease has been made. In this study we wished to determine if there are any clinical features of the disease that may be useful for the identification of genetic susceptibility loci associated with the disorder.