A photocaged, pH-sensitive anion transporter with AND logic dual-stimuli activation.

A pH-switchable anion transporter 1 was photocaged with two photolabile groups to enhance spatiotemporal control over its chloride transport activity. Simultaneous application of light irradiation and acidic pH restores the activity of 1, while either stimulus alone results in no or very low activity. The double activation strategy described herein has potential to yield more selectively cytotoxic anionophores for future medical applications.

pH-Dependent transport of amino acids across lipid bilayers by simple monotopic anion carriers.

The transport of amino acids across lipid membranes is vital for the proper functioning of every living cell. In spite of that, examples of synthetic transporters that can facilitate amino acid transport are rare. This is mainly because at physiological conditions amino acids predominantly exist as highly polar zwitterions and proper shielding of their charged termini, which is necessary for fast diffusion across lipophilic membranes, requires complex and synthetically challenging heteroditopic receptors.