Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia.

Background: Paediatric community-acquired pneumonia (CAP) is a leading cause of paediatric morbidity. However, particularly for outpatients with paediatric CAP, data on aetiology and management are scarce.

Methods: The prospective pedCAPNETZ study multicentrically enrols children and adolescents with outpatient-treated or hospitalised paediatric CAP in Germany.

PedCAPNETZ - prospective observational study on community acquired pneumonia in children and adolescents.

Background: Pediatric community acquired pneumonia (pedCAP) is one of the leading causes for childhood morbidity accounting for up to 20% of pediatric hospital admissions in high income countries. In spite of its high morbidity, updated epidemiological and pathogen data after introduction of preventive vaccination and novel pathogen screening strategies are limited. Moreover, there is a need for validated recommendations on diagnostic and treatment regimens in pedCAP.

[Symposium: Pneumonia 2010 - state of the art].

Community-acquired pneumonia (CAP) is associated with significant morbidity and mortality. It ranks as the fourth leading cause of death in the Western industrialized countries. New insights in the epidemiology and pathogenesis, recent developments in diagnosis and risk-stratification, and current recommendations on prevention and therapy were presented at the symposium "Pneumonie 2010 - State of the Art", held in Kassel, Germany, on the 4.

Influenza vaccination is associated with reduced severity of community-acquired pneumonia.

Pneumonia is an important cause of influenza-associated morbidity and mortality. Influenza vaccination has been shown to reduce morbidity and mortality during influenza seasons. Protection from severe pneumonia may contribute to the beneficial effect of influenza vaccination.

Positive effect of balneotherapy on post-PID symptoms.

Objective: The aim of this study was investigation of effect of balneotherapy after antibiotic treatment of PID.

Patients And Interventions: Fifty-seven patients with PID, diagnosed by laparoscopy, were treated by the same antibiotic scheme (oxytetracycline and metronidazole). After treatment of the acute phase, we studied the effect of balneotherapy (mud baths or mud packs, mineral baths, electrotherapies, and gynecological exercises) under sanatorium conditions in 30 patients.

[Treatment of acute salpingitis with tetracycline/metronidazole with or without additional balneotherapy, Augmentin or ciprofloxacin/metronidazole: a second-look laparoscopy study].

110 patients suffering from laparoscopical verified salpingitis and desire for a baby, were treated with tetracycline (oxytetracycline or doxycycline; TC)/metronidazole (n = 67), augmentan (n = 22) or cipropfloxacin/metronidazole (n = 21). After an average period of 11.6 weeks, all patients underwent second-look laparoscopy with dye insufflation.

[What is the role of cigarette smoking and various methods of contraception in the development of cervix cancer and its precancerous conditions?].

Basis of this trial are examinations of 100 patients with colposcopic and/or cytologic suspicion for precancerous or early stages of cancer of the uterine cervix and of 100 patients in the same age with normal cervical findings. The meaning discussed in literature about cigarette smoking as cofactor for developing cervical cancer and its prestages can be confirmed by our results. The portion of smoking patients with 74 per cent in the cervical groups was higher than in control group (42 per cent).

[Infectious genital diseases and their significance in the development of cervix cancer and its precancerous conditions].

Basis of this trial are examinations of 100 Patients with colposcopic and/or cytologic suspicion for precancerous or early stages of cancer of the uterine Cervix and of 100 patients in the same age with normal cervical findings. Infections conditions vulvitis and condylomata acuminata could be found twice frequent in the cervical group in the control one. Significant differences could be calculated between the two groups with regard to bacterial infections of the vagina (60/22), bacterial vaginosis (54/38) and trichomoniasis (35/22).

[The role of sexual activity in the development of precancerous and early stages of cervix cancer].

100 women average age 30.7 years with colposcopic and/or cytologic suspicion on preinvasive or early invasive cervical carcinoma and 100 women in the same age and with normal cervical tissue as a control group have been compared with regard to their sexual activity. In this study risk factors are early onset of sexual activity combined with frequent change and insufficient sexual hygiene.

[Follow-up in cervix intra-epithelial neoplasia and condylomatous lesions of the uterine cervix].

77 women with colposcopic and/or cytologic suspicious signs had been followed up 6 to 46 months. In 23 (44 per cent) out of 52 women with CIN we could observe progredience, in 19 (37 per cent) cases dysplasias and carcinoma in situ remained unchanged and in 10 (19 per cent) there was a regression. From 18 benign condylomatous lesions 8 were regredient and sones were progredient.

[Colposcopic, cyto- and histologic signs of papilloma virus infection in precancerous and early stages of cervix cancer].

Basis of present study are examinations in 100 women with colposcopic and/or cytologic abnormalities suspect of preinvasive or early invasive carcinoma of the uterine cervix. We found 76 colposcopic abnormal findings in 100 women examined. In 36 women there was a colposcopic suspicion on a papilloma virus infection, in 32 cases combined with abnormal colposcopic findings.

[Ultrastructural papilloma virus detection in precancerous and early stages of cervix cancer].

100 women with pathologic findings in the uterine cervix are the basis of this study. To assess papilloma virus articles methods of electron microscopy have been used in specimens of 59 women if koilocytes were present. Inside the nucleus of koilocytes in 51 cases virus particles could be detected, in 31 cases isolated and in 20 cases agglomerated between the chromatin.

[The incidence of borderline and pathologic findings in young females within the scope of gynecologic-cytologic screening studies].

The frequency of Pap III-V findings in cytological screening examinations in Rostock-City was estimated for the age groups 16-20, 21-25 and 26-30 years. Two 3-year periods (1972-1974 and 1981-1983) were compared. A significant 9-fold increase of cytological results of Pap groups III-V was found during this time.

[Detection of carcinoembryonic antigen (CEA) in cervico-vaginal irrigation fluids].

CEA estimations are effected in serum samples and in cervico vaginal fluids (n = 144) of patients with cervical condylomas, cytological undecided and cytological positive findings and in follow up performed histology. 21 healthy women were used as a control group. For taking cervico-vaginal fluids 5 ml isotonic NaCl solution were instilled in the fornix vaginae.

[Recurrence of choriocarcinoma following methotrexate monotherapy].

Clinical course, diagnosis and therapy of a recurrence of an intramural choriocarcinoma in a women of 26 years are explained. Primary treatment of the patient was only methotrexate. In addition to the clinical findings the results of the HCG determinations are important for the follow-up.

[Incidence, causes and follow-up of doubtful smear findings (Papanicolaou group III)].

Suspect smears of 622 patients from 1977-1986 were analysed for their causes and followed up until the definite cytologic or histologic result. In relation to the overall material of 97,963 cases the rate of suspect smears (group Pap. III) was between 1.

[Detection of human papillomavirus in a cervix precancerous condition. Initial report].

Case report of a 21 years old woman with cervical, vaginal and vulvar condyloma. We have demonstrated the presence of human papilloma viruses (HPV) with help of in-situ-hybridisation.

[Bacterial vaginitis within the scope of gynecologic consultation].

Examinations about bacterial vaginosis have been done in 384 fertile women according the following diagnostic criteria: Homogenous gray flour, typical fish smelling, clue cells and pH of 5 in vaginal content. Clue cells could be detected in 233 (60.6 per cent) women.

[Local treatment of cervical intraepithelial neoplasia with a 5 percent fluorouracil ointment].

The results of treatment of histologically proven cervical intraepithelial neoplasia (CIN) in 10 women are described. Two of them had CIN I and 8 CIN III. All patients had a application of 5 g 5 per cent 5-fluorouracil cream in a cervical cup daily over a period of 12 hours for one week.

[Vulvar cancer originating from pointed condylomas--case report].

A vulvar cancer is demonstrated. Its origin from condylomata acuminata is discussed. The ultrastructural evidence of papillomavirusparticles within the nucleus of koilocytes are hints at a possible human papillomavirus etiology of vulvar carcinoma.

[Experiences with a special consultation for breast diseases].

In this paper results in diagnostics and therapy are presented of 185 patients with breast diseases obtained during special consultation hours. The greatest part of the breast diseases are fibrocystic mastopathies. Very good therapeutic results have been achieved using the phytotherapeutic agent Mastodynon.

[Papilloma virus-induced changes in the uterine cervix. Histo- and cytologic and epidemiologic findings].

In this epidemiological, cytological and histological study signs of papillomavirus infections were found in 128 cases (16,6 per cent) and dysplasia or carcinoma in situ in 713 cases in a series of 773 cone biopsies. Epithelial changes caused by papillomavirus were combined with preneoplastic lesions in 116 cases. Pretherapeutic cytologic examinations of the condylomatous epithelial changes secured histologically later on referred to cervical papillomavirus infections in 64 per cent.

[Endodermal sinus tumor of the ovary--clinical aspects and therapy].

Pathomorphology, clinic and therapy of endodermal sinus tumor in pregnancy are explained and discussed by means of a women of 25 years. The importance of estimation of alpha-fetoprotein with regard to diagnosis and follow up is referred, too. The prognosis in former times very bad could be improved by a combination of radical surgery and polychemotherapy.