Publications by authors named "Bart T H van Dooren"
Corneal guttae, which are the abnormal growth of extracellular matrix in the corneal endothelium, are observed in specular images as black droplets that occlude the endothelial cells. To estimate the corneal parameters (endothelial cell density [ECD], coefficient of variation [CV], and hexagonality [HEX]), we propose a new deep learning method that includes a novel attention mechanism (named fNLA), which helps to infer the cell edges in the occluded areas. The approach first derives the cell edges, then infers the well-detected cells, and finally employs a postprocessing method to fix mistakes.
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- * A large-scale study involving nearly 4,700 keratoconus cases and over 116,000 controls identified 36 genomic regions linked to the disease, highlighting issues with collagen integrity and cell differentiation as crucial factors.
- * The findings reveal shared genetic mechanisms with other corneal diseases and suggest that the identified genetic variants account for 12.5% of keratoconus's genetic risk, paving the way for future diagnostic tests to assess susceptibility.
Purpose: To evaluate the incidence of Acanthamoeba keratitis in the Netherlands between 2009 and 2015 and to analyse predicting factors for treatment outcome.
Methods: Patient characteristics, diagnostic methods, diagnostic delay, therapy prior to and after diagnosis, and visual outcome were obtained from medical files of all patients diagnosed with Acanthamoeba keratitis in the Netherlands between 2009 and 2015. A logistic regression analysis on treatment failure, defined as a best corrected visual acuity of less than 20/40 Snellen decimals (i.
Purpose: To analyze endothelial cell density (ECD) decay after Descemet's stripping automated endothelial keratoplasty (DSAEK) and top hat keratoplasty (THPK) in patients with Fuchs' endothelial dystrophy (FED) and/or pseudophakic bullous keratopathy (PPBK).
Methods: Patients underwent either THPK (n = 33) or DSAEK (n = 39) at the Erasmus Medical Center, Rotterdam. For each nonrandomized cohort, a biexponential regression model for ECD decay was fitted.
Purpose: To report endothelial cell density (ECD) after posterior lamellar keratoplasty (PLK).
Design: Prospective, interventional case series.
Methods: In a single institution, PLK was performed in 15 eyes of 15 patients with pseudophakic bullous keratopathy (PPBK), Fuchs endothelial dystrophy (FED), or both.
Purpose: To report on the calibration of the Topcon SP-2000P specular microscope and the Endothelial Cell Analysis Module of the IMAGEnet 2000 software, and to establish the validity of the different endothelial cell density (ECD) assessment methods available in these instruments.
Methods: Using an external microgrid, we calibrated the magnification of the SP-2000P and the IMAGEnet software. In both eyes of 36 volunteers, we validated 4 ECD assessment methods by comparing these methods to the gold standard manual ECD, manual counting of cells on a video print.
Objective: To quantify the toxicity of trypan blue on human corneal cells according to exposure time and concentration.
Methods: Three in vitro experiments were performed. (1) We exposed cultured human corneal fibroblasts to trypan blue (0.
Purpose: To measure the recipient endothelial cell loss after the Melles technique for deep anterior lamellar keratoplasty.
Methods: In 21 eyes of 21 patients, a deep anterior lamellar keratoplasty procedure was performed. Before surgery and at 6, 12, and 24 months after surgery, specular microscopy was performed to evaluate the endothelial cell density.