A survey among scientists into the current practice of searching for Replacement, Reduction and Refinement (Three Rs) alternatives, highlights the gap between the statutory required need to apply the Three Rs concept whenever possible and the lack of criteria for searching for Three Rs alternatives. A questionnaire was distributed to 342 scientists (Federation of European Laboratory Animal Science Associations [FELASA] Category C and B individuals), of which 67 responded. These scientists are customers of the Central Animal Laboratory of Radboud University Nijmegen Medical Centre.
View Article and Find Full Text PDFA device is described to collect and store continuously time profiles of analytes over periods of 24 h suitable to sample freely moving individuals (humans and animals). The device consists of a hollow fiber ultrafiltration probe, a long capillary and a nonmechanical unit (a disposable medical syringe) driven by vacuum to withdraw fluid. The principle is that at low rates (< or = 100 nL/min), sample fluid is collected through the ultrafiltration probe into the capillary.
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