Publications by authors named "Bart J Eisfelder"
Blood Cancer Discov
May 2024
Article Synopsis
- Myeloid neoplasms, which are linked to clonal hematopoiesis (CH), may also play a role in acute lymphoblastic leukemia (ALL), with 18% of adult ALL cases having TP53 mutations and 16% carrying myeloid CH-related mutations.
- ALL associated with these myeloid mutations displays unique genetic traits and poorer survival outcomes, suggesting it is a high-risk disease.
- Research indicates that myeloid mutations can develop years before an ALL diagnosis, with certain clones becoming dominant, while B-ALL cases respond better to immunotherapy due to alterations in cell survival genes.
