Publications by authors named "Bart Fauser"
Article Synopsis
- Family-planning policies traditionally focused on contraceptives to control population growth, but many countries now experience fertility rates below replacement level, leading to predicted population declines by 2100.
- In response to these declining population trends, countries are exploring child-friendly policies, including financial incentives and limited funding for fertility treatments, to encourage family growth.
- The IFFS consensus document highlights disparities in access to fertility care and emphasizes the need for a broader understanding of family building, encompassing various methods like natural conception, ART, surrogacy, and adoption.
Besides age, estrogen exposure plays a crucial role in changes in bone density (BD) in women. Premature ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS) are conditions in reproductive-aged women in which the exposure to estrogen is substantially different. Women with a history of preeclampsia (PE) are expected to have normal estrogen exposure.
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- Understanding the cardiovascular risk for women with polycystic ovary syndrome (PCOS) is important, especially when considering the impact of hyperandrogenism over time.
- A study compared the cardiometabolic profiles of three groups of women: those consistently hyperandrogenic (HA-HA), those who transitioned to normoandrogenic (HA-NA), and those who were normoandrogenic (NA-NA) over nearly 16 years.
- Results showed that both HA-HA and HA-NA groups had higher body mass indexes, blood pressure, and unfavorable cholesterol levels, indicating a higher risk for cardiovascular disease, although calcium scores and coronary plaque prevalence were similar across all groups.
Background And Aims: To understand pathophysiological mechanisms underlying migraine as a cardiovascular risk factor, we studied neuropeptide action and endothelial function as measures of peripheral microvascular function in middle-aged women with or without migraine.
Methods: We included women with the endocrine disorder polycystic ovary syndrome (PCOS), a population with supposed elevated cardiovascular risk, with and without comorbid migraine. In 26 women without and 23 women with migraine in the interictal phase (mean age 50.
Research Question: Which patient features predict the time to pregnancy (TTP) leading to term live birth in infertile women diagnosed with polycystic ovary syndrome (PCOS)?
Design: Prospective cohort follow-up study was completed, in which initial standardized phenotyping was conducted at two Dutch university medical centres from January 2004 to January 2014. Data were linked to the Netherlands Perinatal Registry to obtain pregnancy outcomes for each participant. All women underwent treatment according to a standardized protocol, starting with ovulation induction as first-line treatment.
The practice of ovarian stimulation for IVF is undergoing a fundamental re-evaluation as recent data begin to successfully challenge the traditional paradigm that ovarian stimulation should be aimed at the retrieval of as many oocytes as possible, in the belief that this will increase pregnancy rates. An opposing view is that live birth rate should not be the only end-point in evaluating the success of IVF treatment and that equal emphasis should be placed on safety and affordability. The International Society for Mild Approaches in Assisted Reproduction (ISMAAR) committee has carried out an up-to-date literature search, with the evidence being graded according to the University of Oxford's Centre for Evidence-Based Medicine.
View Article and Find Full Text PDFObjective: To determine the prevalence of incidental findings (IFs) on coronary computed tomography (CCT) in women aged 45-55 years and previously diagnosed with reproductive disorders such as polycystic ovary syndrome (PCOS), premature ovarian insufficiency (POI) or preeclampsia (PE).
Methods: A total of 486 middle-aged women with PCOS (n = 101), POI (n = 97) or a history of PE (n = 288) underwent a CCT as part of a prior prospective study. IFs were categorized by their significance (minor, moderate and major).
Article Synopsis
- Polycystic ovary syndrome (PCOS) is a common endocrine disorder that causes fertility issues primarily due to high androgen levels.
- A study tested the effectiveness and safety of the NK3 receptor antagonist fezolinetant in reducing testosterone levels in women with PCOS.
- Results showed that fezolinetant significantly lowered total testosterone and improved the LH-to-FSH ratio, indicating its potential as a treatment for PCOS-related hyperandrogenism, with no major safety concerns.
Early Onset of Coronary Artery Calcification in Women With Previous Preeclampsia.
Circ Cardiovasc Imaging
November 2020
Background: Preeclampsia, coronary artery calcification (CAC), and atherosclerotic plaque are risk factors for the development of cardiovascular disease. We determined at what age CAC becomes apparent on coronary computed tomography after preeclampsia and to what extent modifiable cardiovascular risk factors were associated.
Methods: We measured cardiovascular risk factors, CAC by coronary computed tomography, and coronary plaque by coronary computed tomography angiography in 258 previously preeclamptic women aged 40-63.
Background: Regular menstrual cycling during the reproductive years is an indicator of spontaneous ovulation but sometimes falsely perceived as an indicator of preserved fertility. In contrast, menstrual cycle shortening, a physiologic occurrence preceding the menopausal transition, is not usually perceived as an indicator of decreased ovarian reserve in the general population.
Objective And Rationale: The individual decrease in menstrual cycle length (MCL) might represent a sensitive biomarker of diminishing ovarian reserve.
Background: Cardiovascular disease (CVD) is the leading cause of death in women worldwide. The cardiovascular risk profile deteriorates after women enter menopause. By definition, women diagnosed with premature ovarian insufficiency (POI) experience menopause before 40 years of age, which may render these women even more susceptible to develop CVD later in life.
View Article and Find Full Text PDFUnlabelled: Introduction: Preeclampsia (PE) represents a hypertensive pregnancy disorder that is associated with increased cardiovascular disease (CVD) risk. This increased risk has been attributed to accelerated atherosclerosis, with inflammation being a major contributor. Neutrophils play an important role in the onset and progression of atherosclerosis and have been associated with vascular damage in the placenta as well as the chronic inflammatory state in women with PE.
View Article and Find Full Text PDFBackground: Women diagnosed with polycystic ovary syndrome (PCOS) suffer from an unfavorable cardiometabolic risk profile, which is already established by child-bearing age.
Objective And Rationale: The aim of this systematic review along with an individual participant data meta-analysis is to evaluate whether cardiometabolic features in the offspring (females and males aged 1-18 years) of women with PCOS (OPCOS) are less favorable compared to the offspring of healthy controls.
Search Methods: PubMed, Embase and gray literature databases were searched by three authors independently (M.