Publications by authors named "Bart Faes"
Int J Mol Sci
November 2021
Article Synopsis
- Clinical and animal studies indicate that the chemotherapeutic drug doxorubicin (DOX) increases arterial stiffness, which is linked to cardiovascular risk, although results on its effects on vascular smooth muscle cell (VSMC) function have been inconsistent.
- This study administered DOX to mice and examined VSMC contraction, finding reduced contraction after DOX treatment, particularly affecting the tonic phase related to calcium influx.
- Interestingly, while DOX reduced VSMC contraction in ex vivo settings, it did not impact arterial stiffness in vivo, suggesting that the timing of assessments in DOX-treated patients is crucial.
