The Synergistic Effect of High Intensity Focused Ultrasound on In-vitro Remineralization of Tooth Enamel by Calcium Phosphate Ion Clusters.

Background: Remineralization of dental enamel is an important intervention strategy for the treatment of demineralized lesions. Existing approaches have limitations such as failure to adequately reproduce the ideal structural mechanical properties of the native tooth. The ability of ultrasound to control and accelerate the crystallization processes has been widely reported.

Evaluation of Antibacterial Efficacy of High-Intensity Focused Ultrasound Versus Photodynamic Therapy Against Enterococcus faecalis-Infected Root Canals.

Objective: The high incidence of endodontic failure is associated with the remnants of Enterococcus faecalis present within the intricate anatomies of the root canal system (RCS), often inaccessible by the current endodontic practices. This study was aimed at evaluating the effect of high-intensity focused ultrasound (HIFU) and photodynamic therapy (PDT) on E. faecalis biofilms in artificially infected root canals for the potential application in current endodontic practices.

Development of 3D printed dental resin nanocomposite with graphene nanoplatelets enhanced mechanical properties and induced drug-free antimicrobial activity.

Objectives: Oral prosthetic rehabilitation has been used for a long time to restore function and natural appearance; however, it is still one of the most challenging areas in dentistry due to its technical fabrication process and biological behavior. Considering the advantages of additive manufacturing technology, this study introduced the feasibility of developing a 3D printed resin-based composition modified with graphene nanoplatelets (GNPs) to improve properties.

Methods: Acrylate-based resin was impregnated with different concentrations of GNPs (0.

Silver-loaded mesoporous silica nanoparticles enhanced the mechanical and antimicrobial properties of 3D printed denture base resin.

The aim of this study is to develop a novel 3D printed denture base resin material modified with mesoporous silica nanocarrier loaded with silver (Ag/MSN) to enhance mechanical and antimicrobial properties. Acrylate resin-based was incorporated with various proportion of Ag/MSN (0.0-2.

Cytotoxicity and antimicrobial efficiency of ZrO nanoparticles reinforced 3D printed resins.

Objective: The aim of this study was to investigate the potential antimicrobial and cytotoxic effect of modified 3D printed resin with ZrO nanoparticles, as long-term provisional restoration. In addition, the study involved artificial aging process for three months to observe stability of 3D printed resin.

Methods: Functionalized ZrO nanoparticles with γ-MPS were characterized using transmission electron microscopy, scanning electron microscope and Fourier-transform infrared spectroscopy.

Effect of post-curing light exposure time on the physico-mechanical properties and cytotoxicity of 3D-printed denture base material.

Objective: This study investigated the effect of post curing light exposure time on the physico-mechanical properties and cytotoxicity of a 3D-printed PMMA-based denture material in comparison to a conventional heat-cured alternative as a control.

Methods: 3D-printed specimens were fabricated followed by post-curing for 0, 5, 10 or 20 min at 200 W and light wavelength range of 390-540 nm. Heat-cured specimens were fabricated using a standard protocol.

Silanization of nanographene platelets improves interaction with the dentin bonding resin matrix and enhances interfacial bond integrity to dentin.

This study synthesized and characterized graphene nanoplatelets silanized with 3-(trimethoxysilyl)propyl methacrylate (MPS-GNP) for morphological and chemical characteristics. In addition, we modified a dentin bonding agent using different concentrations of MPS-GNP to study its interaction within the resin matrix of the adhesive, degree of conversion (DC), biological, and mechanical properties after bonding to tooth. Both 0.

Adapting World Health Organization Disability Assessment Schedule 2.0 for Nepal.

Background: Disability is a vital public health issue for health care programs. Affluent countries usually prioritize disability-related research, while often it remains neglected in resource-poor countries like Nepal. The aim of this study was to make available a translated and culturally adapted version of the World Health Organization Disability Assessment Schedule 2.

Depression and Quality of Life among the Chronic Kidney Disease Patients.

Background: Depression and other mental illness are very common among chronic kidney disease and also Quality of life has been found significantly impaired in chronic kidney disease. The objective of our study is to study Depression, Quality of life and its associations in chronic kidney disease.

Methods: This was a descriptive cross-sectional study.

Periodontal Health Status and Pregnancy Outcomes: A Survey in Medical Doctors.

Introduction: Periodontal disease and caries are the most common causes of tooth loss worldwide. Studies have demonstrated strong association between periodontitis and adverse pregnancy outcomes. Medical doctors, who are the primary healthcare providers, seldom advise women to seek dental care during pregnancy.

Widespread intra-dependencies in the removal of introns from human transcripts.

Research into the problem of splice site selection has followed a reductionist approach focused on how individual splice sites are recognized. Early applications of information theory uncovered an inconsistency. Human splice signals do not contain enough information to explain the observed fidelity of splicing.

Large-scale analysis of branchpoint usage across species and cell lines.

The coding sequence of each human pre-mRNA is interrupted, on average, by 11 introns that must be spliced out for proper gene expression. Each intron contains three obligate signals: a 5' splice site, a branch site, and a 3' splice site. Splice site usage has been mapped exhaustively across different species, cell types, and cellular states.

Involvement of co-repressor LUH and the adapter proteins SLK1 and SLK2 in the regulation of abiotic stress response genes in Arabidopsis.

Background: During abiotic stress many genes that are important for growth and adaptation to stress are expressed at elevated levels. However, the mechanisms that keep the stress responsive genes from expressing under non stress conditions remain elusive. Recent genetic characterization of the co-repressor LEUNIG_HOMOLOG (LUH) and transcriptional adaptor proteins SEUSS-LIKE1 (SLK1) and SLK2 have been proposed to function redundantly in diverse developmental processes; however their function in the abiotic stress response is unknown.