An assessment of the impact of Raman based glucose feedback control on CHO cell bioreactor process development.

Process analytical technology (PAT) tools such as Raman Spectroscopy have become established tools for real time measurement of CHO cell bioreactor process variables and are aligned with the QbD approach to manufacturing. These tools can have a significant impact on process development if adopted early, creating an end-to-end PAT/QbD focused process. This study assessed the impact of Raman based feedback control on early and late phase development bioreactors by using a Raman based PLS model and PAT management system to control glucose in two CHO cell line bioreactor processes.

Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression.

Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to which genetic and environmental risk factors contribute to individual clinical outcomes is unknown. Here, we compared transcriptional responses to hydrocortisone exposure in human induced pluripotent stem cell (hiPSC)-derived glutamatergic neurons and peripheral blood mononuclear cells (PBMCs) from combat veterans with PTSD (n = 19 hiPSC and n = 20 PBMC donors) and controls (n = 20 hiPSC and n = 20 PBMC donors). In neurons only, we observed diagnosis-specific glucocorticoid-induced changes in gene expression corresponding with PTSD-specific transcriptomic patterns found in human postmortem brains.

Raman based chemometric model development for glycation and glycosylation real time monitoring in a manufacturing scale CHO cell bioreactor process.

The Quality by Design (QbD) approach to the production of therapeutic monoclonal antibodies (mAbs) emphasizes an understanding of the production process ensuring product quality is maintained throughout. Current methods for measuring critical quality attributes (CQAs) such as glycation and glycosylation are time and resource intensive, often, only tested offline once per batch process. Process analytical technology (PAT) tools such as Raman spectroscopy combined with chemometric modeling can provide real time measurements process variables and are aligned with the QbD approach.

Old age psychiatry in the house: assessing the impact of a service transition from consultation to liaison old age psychiatry.

Objective: The impact of a change in service delivery in a psychogeriatric service, moving from a consultation model to liaison model of care, was examined in a naturalistic study.

Methods: The study period was divided into two phases, defined by the change in service delivery. The impact of the change on (1) referral rate, (2) referrals seen, (3) extent of intervention and (4) clinical characteristics was examined.

Vocally disruptive behavior: A case report and literature review.

Vocally disruptive behavior (VDB) is a common and particularly difficult symptom to manage in dementia. VDB is usually considered collectively with agitation and aggression as a component of behavioral and psychological symptoms in dementia and is therefore poorly understood as an individual symptom. A review of the literature is described where VDB as a challenging behavior has been individually examined as a symptom.

Treatment of Desire Discrepancy: One Clinician's Approach.

For couples, the most common sexual problems that arise in therapy are low desire and desire discrepancy. The complex and challenging nature of desire discrepancy is addressed, along with core therapeutic interventions to confront the traditional power struggle over defining sex as intercourse only. The importance of desire is recognized in understanding that sexual satisfaction means feeling good about oneself as a sexual person and energized as a sexual couple.

Expanding the Types of Clients Receiving Sex Therapy and Sexual Health Services.

The provision of sex therapy primarily occurs for middle-class couples by middle-class clinicians. This conceptual/clinical article advocates for sex therapy approaches that better meet the needs of individuals and couples within a broader socioeconomic range, and includes two case studies as examples. Every couple, regardless of socioeconomic status, deserves first-class sex therapy that helps establish a satisfying, secure, and sexual relationship from an empathic, respectful clinician who remains sensitive to specific vulnerabilities and challenges related to economic and social class factors.

Factors Associated With Marital Satisfaction in Infertile Couple: A Comprehensive Literature Review.

Background: Many factors impact on marital satisfaction. Related factors include demographic factors, assisted reproductive techniques, psychological health, quality of life, psychological, socioeconomic and family support, and sexual function.

Methods: This study is a literature review of research studies conducted on factors associated with marital satisfaction in infertile couples.

Sexual challenges with aging: integrating the GES approach in an elderly couple.

An advantage of sexuality after 60 years of age is the increased need for couple involvement to promote desire, pleasure, eroticism, and satisfaction inherent to the healthy aging process. This case study clinically explores the complex psychobiosocial interactions for understanding, assessing, and treating sexual problems for couples age 60 years and older, emphasizing the Good Enough Sex approach of variable, flexible, and shared sexual pleasure. Aging couples are discouraged from appraising their sexual experiences within the parameters of the pass/fail binary of the traditional individual performance model and are instead encouraged to embrace the evolving elasticity of their sexual experiences.

New strategies in assessing, treating, and relapse prevention of extramarital affairs.

Understanding, assessing, treating, and preventing relapse of extra-marital affairs has involved significant changes in the past 10 years. This conceptual/clinical article expands on the groundbreaking work of Snyder, Gordon, and Baucom (2007), and has a special focus placed on the process of sexual recovery from an extra-marital affair. Secondly, this article focuses on the importance of creating a relapse prevention agreement.

The impact of sexual trauma on sexual desire and function.

The field of sexual trauma is one of the most controversial and value-laden in mental health. The three factors which most affect adult sexual desire and function are the type of sexual trauma, how the sexual incidents were dealt with at the time and, most important, whether the person views her/himself as a survivor or victim. The assessment and treatment program described focuses on couple sex therapy with a special focus on processing the sexual trauma, honoring the person's veto and being 'partners in healing'.

Sex therapy failures: a crucial, yet ignored, issue.

There are a range of factors that can cause sex therapy failure including biological/medical, psychological, relational, and relapse prevention issues. The goal of this article is to generate conceptual, empirical, and clinical interest in the crucial, yet ignored, problem of sex therapy failure.

Men, intimacy, and eroticism.

Introduction: We present a conceptual/clinical article focused on the Good-Enough Sex model of male and couple sexuality. This offers a comprehensive, integrative couple approach to understanding and treating male sexual dysfunction.

Aim: To examine the couple biopsychosocial approach to assessing and treating male sexual dysfunction.

Integrating medication, realistic expectations, and therapeutic interventions in the treatment of male sexual dysfunction.

Male sexuality in adolescence and early adulthood is characterized by autonomous, predictable erections. As males age, however, their arousal becomes less predictable and more dependent on partner interaction. This transition can produce anxiety.

Patterns and universals of mate poaching across 53 nations: the effects of sex, culture, and personality on romantically attracting another person's partner.

As part of the International Sexuality Description Project, 16,954 participants from 53 nations were administered an anonymous survey about experiences with romantic attraction. Mate poaching--romantically attracting someone who is already in a relationship--was most common in Southern Europe, South America, Western Europe, and Eastern Europe and was relatively infrequent in Africa, South/Southeast Asia, and East Asia. Evolutionary and social-role hypotheses received empirical support.

Universal sex differences in the desire for sexual variety: tests from 52 nations, 6 continents, and 13 islands.

Evolutionary psychologists have hypothesized that men and women possess both long-term and short-term mating strategies, with men's short-term strategy differentially rooted in the desire for sexual variety. In this article, findings from a cross-cultural survey of 16,288 people across 10 major world regions (including North America, South America, Western Europe, Eastern Europe, Southern Europe, Middle East, Africa, Oceania, South/Southeast Asia, and East Asia) demonstrate that sex differences in the desire for sexual variety are culturally universal throughout these world regions. Sex differences were evident regardless of whether mean, median, distributional, or categorical indexes of sexual differentiation were evaluated.

Sexual secrets, trauma, and dysfunction.

The majority of people who present for couple sex therapy have sexual secrets, often involving both past and present experiences. This article explores the most-common sexual secrets, the ways that secrets can subvert treatment, the decision whether to share secrets, techniques for sharing secrets, and the motivating impact on marital trust and sexuality of confronting secrets.