Publications by authors named "Barry D Gehm"
Resveratrol, a hydroxystilbene found in grapes and wine, has previously been shown to be a non-flavonoid phytoestrogen, and to act as an estrogen receptor (ER) superagonist in MCF-7 cells transiently transfected with estrogen-responsive reporter constructs. Several additional hydroxystilbenes, including diethylstilbestrol (DES) and piceatannol, were tested, and all showed ER agonism or partial agonism, but superagonism was specific to resveratrol. Moreover, superagonism was observed in cells carrying a stably integrated reporter gene, indicating that this phenomenon is not a result of transient transfection.
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- Resveratrol (Res) is a compound found in grapes and red wine that acts like estrogen, which can affect breast cancer cells in two ways: it can stimulate their growth or help block their growth.
- In studies, Res showed it could increase levels of a specific gene (TGFalpha) that indicates it acts as an estrogen, but it does not work against estrogen when both are present.
- Res also seems to affect different types of estrogen receptors in breast cancer cells by lowering one type and raising another, and it activates many genes that may help stop cell growth.