Publications by authors named "Barreto-Luis A"

In the version of this article initially published, in Fig. 3, the y-axis numbering did not match the log scale indicated in the axis label. The error has been corrected in the HTML and PDF version of the article.

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Article Synopsis
  • Allergic rhinitis, affecting 400 million people globally, is on the rise in western countries, prompting a detailed genetic analysis involving 59,762 cases and 152,358 controls to identify risk factors.
  • The study found 41 genetic loci linked to allergic rhinitis, including 20 previously unidentified, and validated these findings in an additional group of 60,720 cases and 618,527 controls.
  • The research suggests that common genetic mechanisms underlie different types of rhinitis, paving the way for potential new treatment and prevention strategies targeting the identified genetic factors.
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Background: Genetic susceptibility to asthma is currently linked to a handful of genes which have a limited ability to predict the overall disease risk, suggesting the existence of many other genes involved in disease development. Accumulated evidence from association studies in genes related by biological pathways could reveal novel asthma genes.

Objective: To reveal novel asthma susceptibility genes by means of a pathway-based association study.

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