Clinical and In Vitro Safety of AO 1167B: A Double-Blind, Placebo-Controlled Trial.

(1) Background: , a lactic acid-producing bacterium, displays characteristics of both and genera. Clinical evidence suggests its potential health benefits. This study evaluated the safety of AO1167B as a candidate probiotic supplement.

In Vitro Evaluation of the Antifungal Properties of L. Essential Oil from the Ecuadorian Amazon Against (ATCC 10231).

Essential oils are investigated due to their biological activity, and the Amazon rainforest, with its rich biodiversity, is a promising source of therapeutic compounds. The aim of this study was to evaluate the essential oil from the leaves of as an antifungal agent, thus contributing to the search for alternatives that can address the growing resistance to conventional antifungals. leaves were collected in the Ecuadorian Amazon and their essential oil was obtained by steam distillation.

Crystal structure of Au-pseudocarbyne(C).

Carbyne-related materials permit exploring the potentially extraordinary properties of this long-sought but still elusive carbon allotrope. However, accurate understanding of these materials is challenging. Here we report the crystal structure of a Au-pseudocarbyne, a representative of a possible new family of materials consisting of sp-hybridized carbon chains and stabilizing metal atoms.

Dapagliflozin reduces the white coat effect on systolic blood pressure of patients with type 2 diabetes: a analysis from the ADDENDA-BHS 2 trial.

Background: White coat effect (WCE) is a phenomenon linked to increased cardiovascular risk, where office blood pressure readings exceed home or ambulatory measurements. Excess weight and elevated blood pressure or glucose are associated with WCE in type 2 diabetes (T2D). This study compared dapagliflozin and glibenclamide on WCE in T2D patients under equivalent blood pressure and glucose control.

Ultrathin Films of a Nitrile-Functionalized Ionic Liquid [CCNCIm][TfN] on Au(111) and Pt(111): Adsorption, Growth, and Thermal Behavior.

We studied the adsorption and thermal behavior of the nitrile-functionalized ionic liquid (IL) [CCNCIm][TfN] on Au(111) and Pt(111) between 150 and 600 K. Ultrathin films were prepared at 150 K by physical vapor deposition (PVD) and were characterized by angle resolved X-ray photoelectron spectroscopy (ARXPS). At 150 K, the IL adsorbs intact with a similar orientation on both surfaces: In the first layer, the so-called wetting layer, the cation lies flat on the surface and the anion is bound in -configuration with the SO groups toward the surface and the CF groups away from the surface.

Bedaquiline Monotherapy for Multibacillary Leprosy.

Background: Standard multidrug therapy for leprosy may be associated with severe side effects, which add to the stigma and discrimination that affect persons with the disease. In addition, the threat posed by drug-resistant leprosy shows the need for alternative drug combinations and shorter, safer regimens of multidrug therapy.

Methods: In this open-label, proof-of-concept study conducted in Brazil, we assigned patients with previously untreated multibacillary leprosy to receive bedaquiline monotherapy for 8 weeks.

Challenges in renally eliminated medication use: Evaluating cystatin C and serum creatinine eGFR discordance.

Background: Accurately estimating glomerular filtration rate (GFR) is crucial for dosing medications in hospitalized patients. Due to limitations of serum creatinine for GFR estimation, serum cystatin C (CysC) has been explored as an alternative functional kidney biomarker. This study assessed discordance between eGFR and eGFR in a large sample of hospitalized patients and examined the frequency of renally eliminated medications affected by eGFR discordance.

Effects of body-oriented intervention after stroke on cognitive function, body awareness, and quality of life: A systematic review.

Background: Some cognitive functions can be affected by a stroke as it causes sensory, perceptual, and visual deficits, contributing to a loss of body awareness and changes in one's body image and leading to a decrease in the quality of life (QoL). This systematic review aims to identify and systematize scientific evidence of body-oriented intervention (BOI) effects in adult and elderly patients after a stroke on cognitive function, body awareness, and QoL.

Methods: The research was carried out in: Pubmed, Science Direct, Cochrane, Web of Science, Psycinfo, Scopus, Portal Regional da BVS, and PEDro.

A Surface-Active Pt(II) Bis-N-Heterocyclic Carbene (NHC) Complex for Interface-Enhanced Supported Ionic Liquid Phase (SILP) Catalysis.

We present the preparation and investigation of a fluorine-free surface-active bis-N-heterocyclic carbene (NHC) platinum(II) complex - trans-[Pt(mPEGCIm)Cl] - for interface-enhanced supported ionic liquid phase (SILP) catalysis within a group of (mPEG)-substituted ionic liquids (ILs) ([(mPEG)Im][A] ILs). The complex was characterized by means of single-crystal X-ray diffraction (scXRD) analysis and multinuclear (H, C, Pt) NMR spectroscopy, indicating the presence of two almost equimolar syn-anti-rotamers of the square-planar complex in solution. Angle-resolved X-ray photoelectron spectroscopy (ARXPS) revealed pronounced interface-accumulation of trans-[Pt(mPEGCIm)Cl] in IL solutions of [(mPEG)Im][A] (A=I and PF ).

Pharmaceutical Telemonitoring for Patients With Psychiatric Disorders: Implementation Description.

Telecare has exhibited efficacy in managing various chronic clinical conditions and presents potential in the surveillance of patients with psychiatric disorders, an area necessitating further investigation. Herein, we delineate an adjunct for pharmacotherapeutic oversight of individuals with psychiatric disorders receiving care at a public mental health outpatient facility. This manuscript serves as an implementation dossier detailing the progression of a preliminary trial.

Multiplet XPS analysis of the Mn 2for MnOthin films.

In this work, we performed a detailed analysis of the x-ray photoemission spectroscopy (XPS) of the Mn 2peak for MnO(001) thin films. This is a challenging task since MnOis composed of two different cations, Mnat tetrahedral and Mnat octahedral sites, which both contribute to the XPS spectra. The oxide spectra consist of many multiplets arising from the angular momentum coupling of the open Mn 2and 3shells, thus increasing the spectrums' complexity.

Diacerein reduces inflammasome activation and SARS-CoV-2 virus replication: a proof-of-concept translational study.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is linked to high mortality, primarily through an intense inflammatory response. Diacerein has emerged as a potential therapy for COVID-19 due to its potential impact in decreasing the inflammasome activation and coronavirus replication. This study aims to explore diacerein's influence in inhibiting both viral replication and the inflammatory response after SARS-CoV-2 infection.

Orthostatic blood pressure phenotypes prevalence in type 2 diabetes mellitus.

Background And Aims: Orthostatic hypotension (Ohypo) and hypertension (Ohyper) have emerged early markers for high risk of cardiovascular events. Data on the prevalence and risk factors of Ohypo and Ohyper in patients with type 2 diabetes (T2D) are scarce.

Methods: Within the framework of the Brazilian Diabetes Study, this is an observational, cross-sectional study.

Inclusion of disability in primary healthcare facilities and socioeconomic inequity in Brazil.

Objective: To describe disability-related performance and inequality nationwide in Brazil, and the changes that took place between 2012 and 2019 after the introduction of Programme for Improving Primary Care Access and Quality (PMAQ).

Methods: We derived scores for disability-related care and accessibility of primary healthcare facilities from PMAQ indicators collected in round 1 (2011-2013), and round 3 (2015-2019). We assessed how scores changed after the introduction of PMAQ.

[Evidence for Health Promotion in Brazil: report on a rapid response serviceEvidencia para la promoción de la salud en Brasil: informe sobre un servicio de respuesta rápida].

Objective: Present the experience of a rapid response service to support decision-making in health systems.

Methodology: Description of the processes and results of a service that produces rapid reviews and evidence maps to support decision-making under the National Health Promotion Policy, as well as the authors' perception of the work process.

Results: The rapid response service started in 2020.

Skin accumulation of advanced glycation end-products predicts kidney outcomes in type 2 diabetes: results from the Brazilian Diabetes Study.

The accumulation of advanced glycation end-products (AGEs) elicits morphofunctional kidney impairment. AGEs levels can be noninvasively estimated by skin autofluorescence (SAF). We explored whether high SAF predicts kidney outcomes in type 2 diabetes (T2D) individuals.

Longitudinal seroepidemiological survey and risk factors for bluetongue virus infection in sheep in the state of Parana, Brazil, from 2014 to 2017.

The Bluetongue disease is an infectious and non-contagious viral disease mainly transmitted through hematophagous vector of the Culicoides genus, to domestic and wild ruminants. The aim of this study was to evaluate the antibodies occurrence, persistence and potential risk factors associated with bluetongue virus infection in sheep flocks in the state of Parana, Brazil. The competitive ELISA test was applied to evaluate 690 blood serum samples from 22 farms in eight mesoregions of Parana in 2014, and 270 sheep blood serum samples from 10 of the 22 previously studied farms in 2017.

Appropriate Delivery Project: Impact of Simulation Training on the Increase in Vaginal Births in Hospitals in Brazil.

Objective: This study aimed to analyze the relationship between the participation of professionals in simulation-based training and an increase in the rate of vaginal deliveries.

Methods: This retrospective observational study analyzed professionals' participation in high-fidelity simulation training during the pilot phase of the Appropriate Delivery Project, spanning from May 21, 2015 to May 21, 2016, along with the rates of vaginal deliveries across various hospitals. Data for participation by nurses and physicians were examined using a gamma distribution model to discern the predictors influencing the changes in the percentage of vaginal births.

Research evidence communication for policy-makers: a rapid scoping review on frameworks, guidance and tools, and barriers and facilitators.

Background: Communication is a multifaceted process, ranging from linear, one-way approaches, such as transmitting a simple message, to continuous exchanges and feedback loops among stakeholders. In particular the COVID-19 pandemic underscored the critical need for timely, effective and credible evidence communication to increase awareness, levels of trust, and evidence uptake in policy and practice. However, whether to improve policy responses in crises or address more commonplace societal challenges, comprehensive guidance on evidence communication to decision-makers in health policies and systems remains limited.