Droplet Core Intermolecular Interactions and Block Copolymer Composition Heavily Influence Oil-In-Water Nanoemulsion Stability.

Colloidal oil-in-water nanoemulsions are gaining increasing interest as a nanoparticle delivery system because of their large oil droplet core that can carry a large payload. In order to formulate these particles with long-term stability, an appropriate oil media and block copolymer pair must be selected. The interaction between the nanoemulsion core and the polymer shell is critical to forming stable nanoparticles.

Predictive factors of intracranial bleeding in head trauma patients receiving antiplatelet therapy admitted to an emergency department.

Background: In head trauma cases involving antiplatelet agent treatment, the French Society of Emergency Medicine recommends performing computed tomography (CT) scans to detect brain lesions, 90% of which are normal. The value of CT is still debatable given the scarce number of studies and controversial results.

Methods: We used the RATED registry (Registry of patient with Antithrombotic agents admitted to an Emergency Department, NCT02706080) to assess factors of cerebral bleeding related to antiplatelet agents following head trauma.

Experimental study of the sensitivity of a porous silicon ring resonator sensor using continuous in-flow measurements.

A highly sensitive photonic sensor based on a porous silicon ring resonator was developed and experimentally characterized. The photonic sensing structure was fabricated by exploiting a porous silicon double layer, where the top layer of a low porosity was used to form photonic elements by e-beam lithography and the bottom layer of a high porosity was used to confine light in the vertical direction. The sensing performance of the ring resonator sensor based on porous silicon was compared for the different resonances within the analyzed wavelength range both for transverse-electric and transverse-magnetic polarizations.

Multicompartment Theranostic Nanoemulsions Stabilized by a Triphilic Semifluorinated Block Copolymer.

The presence of a perfluorocarbon block in a multiblock polymer has been shown to be an additional driving force toward nanoparticle assembly. In the preparation of nanoemulsions, this perfluorocarbon block also provides enhanced particle stability. Herein, the synthesis of a new triphilic, semifluorinated copolymer, M2F8H18, is introduced.

Assessment of the Impact of L-Thyroxine Therapy on Bleeding Risk in Patients Receiving Vitamin K Antagonists.

Background: Several studies have suggested a link exists between L-thyroxine and the coagulation system, and, according to some drug interaction studies, L-thyroxine can potentiate the effect of warfarin. This study sought to assess whether thyroid hormone therapy could impact the risk of bleeding in patients receiving vitamin K antagonists (VKAs).

Methods: We conducted a monocentric, retrospective study on prospectively collected data from consecutive patients enrolled in the Registry of patient with AntiThrombotic agents admitted to an Emergency Department (RATED) database, and compared the hemorrhage rates (both major and nonmajor) of patients receiving treatment with and without L-thyroxine.

Voltage gain in lithiated enolate-based organic cathode materials by isomeric effect.

Li-ion batteries (LIBs) appear nowadays as flagship technology able to power an increasing range of applications starting from small portable electronic devices to advanced electric vehicles. Over the past two decades, the discoveries of new metal-based host structures, together with substantial technical developments, have considerably improved their electrochemical performance, particularly in terms of energy density. To further promote electrochemical storage systems while limiting the demand on metal-based raw materials, a possible parallel research to inorganic-based batteries consists in developing efficient and low-polluting organic electrode materials.

Electrochemical properties of crystallized dilithium squarate: insight from dispersion-corrected density functional theory.

The stacking parameters, lattice constants, and bond lengths of solvent-free dilithium squarate (Li(2)C(4)O(4)) crystals were investigated using density functional theory with and without dispersion corrections. The shortcoming of the GGA (PBE) calculation with respect to the dispersive forces appears in the form of an overestimation of the unit cell volume up to 5.8%.

High-potential reversible Li deintercalation in a substituted tetrahydroxy-p-benzoquinone dilithium salt: an experimental and theoretical study.

Efficient organic Li-ion batteries require air-stable lithiated organic structures that can reversibly deintercalate Li at sufficiently high potentials. To date, most of the cathode materials reported in the literature are typically synthesized in their fully oxidized form, which restricts the operating potential of such materials and requires use of an anode material in its lithiated state. Reduced forms of quinonic structures could represent examples of lithiated organic-based cathodes that can deintercalate Li(+) at potentials higher than 3 V thanks to substituent effects.

Influence of opioid choice on mechanical ventilation duration and ICU length of stay.

Background: The aim of this study was to assess the impact on mechanical ventilation and ICU outcomes of substituting remifentanil for sufentanil, in an analgesia-based sedation protocol. A database of data prospectively collected was retrospectively analyzed. The study was carried out in a 16-bed tertiary-care ICU.

Asymmetric addition of pyridine to 1,4-bis(ethynyl)bicyclo[2.2.2]octane: dissymmetrical rotator ligands illustrated in dpppPt(II) and [Re6Se8]2+ complexes and an amphidynamic hydrogen bonded framework solid.

A polar function like pyridine increases the polarity difference between mono- and disubstituted 1,4-bis(trimethylsilylethynyl)bicyclo[2.2.2]octane cores allowing for their ready separation by chromatography, affording two dissymmetrical ligands illustrated in metal-rotor hybrids like a corner-shaped mononuclear complex, an octahedral hexanuclear metal complex, and a framework solid with a rather slow rotator.

[Clinical pathway in traumatology, a fashion or need?].

A clinical route is defined as a "set of methods and instruments to members of a multidisciplinary and Interprofessional team to agree on the tasks for a specific patient population. This is a program of care to ensure the provision of quality care and efficient realization". The University Hospital is not immune to this phenomenon.

The 8 : 1 : 1 ternary hybrid framework in the system [EDT-TTF +][1,4-bis(iodoethynyl)benzene][Re6Se8(CN)6]4-: dual noncovalent expression of the octahedral halogen-bond hexa-acceptor nanonode.

Complementary shapes of the neutral symmetrical halogen-bond bis-donor core and octahedral inorganic cluster core prevent halogen-bonded polymers developing in more than one direction, favouring further templating by conducting radical cation slabs and yielding an 8 : 1 : 1 phase formulation instead of n : 2 : 1, with a 2D net, or m : 3 : 1, with a pseudo-cubic architecture, which may in principle also be targeted.

[Quality management at the University Hospital and Orthopedic Hospital of French-speaking Switzerland: coherence in diversity].

All hospitals in Switzerland will have to set up and run a quality management system, according to legal and contract requirements. However, their context and characteristics are quite different, and will have an impact on the type of system they will select and implement. The University Hospital in Lausanne and the Hôpital Orthopédique de la Suisse Romande are neighbour hospitals, which run an orthopaedic ward on both locations.

[Tubo-ovarian actinomycosis].

Pelvic actinomycosis is uncommon and usually represents a complication of an intrauterine device (IUD). This organism is very difficult to culture, and most actinomyces is actually identified by histologic features in pathologic specimens or by cytologic features on Papanicolaou smears. A specific fluorescent antibody stain is also available.

[Complete tumor remission after chemotherapy. What should be done?].

When confronted with complete chemotherapy-induced histological/clinical regression of a tumor, should the initial therapeutical strategy be modified? Such situations occur more and more frequently. Additional treatment must be carried out in all instances. Indeed, a correlation between complete clinical and histological regression was demonstrated in 66% of cases by histological examination of surgical specimens.

[Echography in studying the hyothyroepiglottic space. Normal image. Pathologic aspects. Histologic correlations].

Invasion of the hyothyroepiglottic (HTE) space, or pre-epiglottic space, constitutes an important element in selecting the type of therapy in cancer of the larynx (functional surgery, radiotherapy), the oropharynx and the hypopharynx. Clinical examination and standard X-ray films provide insufficient information. High frequency real time ultrasonography offers a reliable means for exploring the pre-epiglottic space, as evidenced by this study carried on 34 histologically-confirmed cases taken among 77 cases of carcinoma of the upper digestive and respiratory tracts.