Applications, Limitations, and Considerations of Clinical Trials in a Dish.

Recent advancements in biotechnology forged the path for clinical trials in dish (CTiDs) to advance as a popular method of experimentation in biomedicine. CTiDs play a fundamental role in translational research through technologies such as induced pluripotent stem cells, whole genome sequencing, and organs-on-a-chip. In this review, we explore advancements that enable these CTiD biotechnologies and their applications in animal testing, disease modeling, and space radiation technologies.

Partnering with Students to Develop a Capstone for a Graduate Health Informatics Program.

Objective:  This study aimed to assess the desirability, feasibility, and sustainability of integrating a project-based capstone course with the course-based curriculum of an interdisciplinary MSc Health Informatics program guided by a student-partnered steering committee and student-centered approach.

Methods:  We conducted an online cross-sectional survey ( = 87) and three semistructured focus groups ( = 18) of health informatics students and alumni. Survey data were analyzed descriptively.

Predicting homelessness: Housing risk insights from latent class analysis.

Millions of families with children in the U.S. struggle to afford adequate housing.

Towards a better future for DNA barcoding: Evaluating monophyly- and distance-based species identification using COI gene fragments of Dacini fruit flies.

The utility of a universal DNA 'barcode' fragment (658 base pairs of the Cytochrome C Oxidase I [COI] gene) has been established as a useful tool for species identification, and widely criticized as one for understanding the evolutionary history of a group. Large amounts of COI sequence data have been produced that hold promise for rapid species identification, for example, for biosecurity. The fruit fly tribe Dacini holds about a thousand species, of which 80 are pests of economic concern.

Paramedics' experiences of barriers to, and enablers of, responding to suspected or confirmed COVID-19 cases: a qualitative study.

Background: Paramedics' work, even pre-pandemic, can be confronting and dangerous. As pandemics add extra stressors, the study explored paramedics' lived experience of the barriers to, and enablers of, responding to suspected or confirmed Coronavirus Disease 2019 (COVID-19) cases.

Methods: This exploratory-descriptive qualitative study used semi-structured interviews to investigate Queensland metropolitan paramedics' experiences of responding to cases during the COVID-19 pandemic.

Investigating the relationship between changes in metaphysical beliefs and death anxiety following a significant psychedelic experience.

Research examining the potential of the psychedelic experience to alter attitudes toward death is steadily emerging. However, the specific mechanisms leading to this change are not well understood. The present study investigated the potential relationship between changes in metaphysical beliefs and changes in death anxiety following a single significant psychedelic experience.

*SMARTSIM* A multicenter prospective randomized trial of 3D virtual reality versus traditional patient simulation.

Objective: Simulations are an integral part of paramedic education. Technological advancements have introduced three-dimensional virtual reality patient simulations (3DVRS), offering a low-cost, accessible alternative. This study compares the impact of 3DVRS and traditional simulation on paramedic students.

5-MeO-DMT for post-traumatic stress disorder: a real-world longitudinal case study.

Psychedelic therapy is, arguably, the next frontier in psychiatry. It offers a radical alternative to longstanding, mainstays of treatment, while exciting a paradigm shift in translational science and drug discovery. There is particular interest in 5-methoxy--dimethyltryptamine (5-MeO-DMT)-a serotonergic psychedelic-as a novel, fast-acting therapeutic.

Evidence of nitrate-based nighttime atmospheric nucleation driven by marine microorganisms in the South Pacific.

Our understanding of ocean-cloud interactions and their effect on climate lacks insight into a key pathway: do biogenic marine emissions form new particles in the open ocean atmosphere? Using measurements collected in ship-borne air-sea interface tanks deployed in the Southwestern Pacific Ocean, we identified new particle formation (NPF) during nighttime that was related to plankton community composition. We show that nitrate ions are the only species for which abundance could support NPF rates in our semicontrolled experiments. Nitrate ions also prevailed in the natural pristine marine atmosphere and were elevated under higher sub-10 nm particle concentrations.

Insight Problem Solving Ability Predicts Reduced Susceptibility to Fake News, Bullshit, and Overclaiming.

The information humans are exposed to has grown exponentially. This has placed increased demands upon our information selection strategies resulting in reduced fact-checking and critical-thinking time. Prior research shows that problem solving (traditionally measured using the Cognitive Reflection Test-CRT) negatively correlates with believing in false information.

Interspecific gene flow obscures phylogenetic relationships in an important insect pest species complex.

As genomic data proliferates, the prevalence of post-speciation gene flow is making species boundaries and relationships increasingly ambiguous. Although current approaches inferring fully bifurcating phylogenies based on concatenated datasets provide simple and robust answers to many species relationships, they may be inaccurate because the models ignore inter-specific gene flow and incomplete lineage sorting. To examine the potential error resulting from ignoring gene flow, we generated both a RAD-seq and a 500 protein-coding loci highly multiplexed amplicon (HiMAP) dataset for a monophyletic group of 12 species defined as the Bactrocera dorsalis sensu lato clade.

Humans versus AI: whether and why we prefer human-created compared to AI-created artwork.

With the recent proliferation of advanced artificial intelligence (AI) models capable of mimicking human artworks, AI creations might soon replace products of human creativity, although skeptics argue that this outcome is unlikely. One possible reason this may be unlikely is that, independent of the physical properties of art, we place great value on the imbuement of the human experience in art. An interesting question, then, is whether and why people might prefer human-compared to AI-created artworks.

Paramedic insertion of peripheral intravenous catheters, unused catheter rates, and influencing factors: A retrospective review.

Background: Peripheral intravenous catheters (PIVCs) are associated with adverse events such as bloodstream infections; thus clinically appropriate practice is important. However, there is limited research on PIVC use in ambulance settings. This study investigated the incidence of paramedic-inserted PIVCs, unused PIVCs, and factors that influenced practice.

Latent profile analysis of veterans' psychological risk and protective factors: Associations with nonroutine military discharge.

Objective: Veterans with nonroutine military discharge (NRD) often have worse psychosocial outcomes than their routinely discharged peers. However, little is known about how subgroups of veterans vary regarding risk and protective factors like PTSD, depression, self-stigma of mental illness, mindfulness, and self-efficacy, and how subgroup characteristics relate to discharge status. We applied person-centered models to detect latent profiles and associations with NRD.

Housing insecurity and adolescent behavioral outcomes: The mediating role of aggression in parenting.

Background: Housing insecurity impacts millions of families with children each year and is linked with a range of adverse outcomes. Greater understanding of pathways linking housing insecurity with emotional and behavioral problem is needed to prevent enduring mental health problems. The Family Stress Model and Bronfenbrenner's Ecological Model contribute understanding to the complex dynamics underlying development from childhood to adolescence in the context of economic hardship and parental strain.

Pre-hospital peripheral intravenous catheter insertion practice: An integrative review.

Background: Peripheral intravenous catheters (PIVCs) are widely used within healthcare settings. There is substantial hospital-based research, particularly in Emergency Departments, supporting the need to reduce inappropriate PIVCs due to associated risks. However, there is limited research into pre-hospital practice.

Toward a dual process model of moral injury and traumatic illness.

Moral injury has emerged as a topic of significant research and clinical interest over the last decade. However, much work remains to be done to comprehensively define the moral injury construct, with implications for understanding the etiology and maintenance of moral injury, its symptoms, associations with and distinctions from traumatic illness, and treatment approaches. We provide a brief overview of the existing moral injury literature and introduce a novel dual process model (DPM) of moral injury and traumatic illness.

Barriers to, and enablers of, paramedics responding to suspected or confirmed COVID-19 cases: An integrative review.

Background: The coronavirus pandemic (COVID-19) has focused attention on healthcare workers' concerns about working during a pandemic, yet research on the effect of the pandemic specifically on paramedics is lacking. This literature review aims to critically examine the current knowledge of paramedics' experience of barriers to, and enablers of, responding to suspected or confirmed COVID-19 cases.

Methods: An integrative review was undertaken using articles found by a systematic search of four research databases.

The implementation of interprofessional education: a scoping review.

Introduction: Implementation of interprofessional education (IPE) is recognised as challenging, and well-designed programs can have differing levels of success depending on implementation quality. The aim of this review was to summarise the evidence for implementation of IPE, and identify challenges and key lessons to guide faculty in IPE implementation.

Methods: Five stage scoping review of methodological characteristics, implementation components, challenges and key lessons in primary studies in IPE.

An observational study of peripheral intravenous and intraosseous device insertion reported in the United States of America National Emergency Medical Services Information System in 2016.

Objective: To investigate the prevalence of intravenous and interosseous device insertion in the prehospital setting by prehospital clinicians, and the characteristics of patients receiving these devices as reported to the United States of America National Emergency Medical Services Information System.

Methods: A retrospective analysis of the United States of America National Emergency Medical Services Information System public release dataset for the 2016 calendar year.

Results: A total of 20,454,975 events involving 40,438,959 procedures were analysed.

Delineation of a minimal topoisomerase II binding protein 1 for regulated activation of ATR at DNA double-strand breaks.

Topoisomerase II Binding Protein 1 (TOPBP1) is an important activator of the DNA damage response kinase Ataxia Telangiectasia and Rad3-related (ATR), although the mechanism by which this activation occurs is not yet known. TOPBP1 contains nine copies of the BRCA1 C-terminal repeat (BRCT) motif, which allows protein-protein and protein-DNA interactions. TOPBP1 also contains an ATR activation domain (AAD), which physically interacts with ATR and its partner ATR-interacting protein (ATRIP) in a manner that stimulates ATR kinase activity.

Creativity, Boredom Proneness and Well-Being in the Pandemic.

Throughout the course of the pandemic, it has become clear that the strictures of social isolation and various levels of lockdown constraints have impacted people's well-being. Here, our aim was to explore relations between trait dispositions associated with boredom proneness, self-regulation and well-being using data collected early in the pandemic. Specifically, we explored whether the tendency to engage in everyday creative pursuits (e.

Peripheral intravenous catheter and intraosseous device insertions reported from the 1 July 2016 to 30 June 2017 in an Australian state ambulance service: An observational study.

Objective: To overcome the lack of larger, population-based studies reporting the prevalence of insertion of PIVCs and IO devices, and to describe the patient-related and service-related characteristics of these devices, inserted by paramedics, in an Australian state ambulance service.

Methods: A retrospective analysis of the electronic Ambulance Report Form (medical record) and Computer Aided Dispatch system from the 1st July 2016 until 30th June 2017.

Results: 709,217 events were analysed.