Publications by authors named "Barone A"
Few studies using Positron Emission Tomography with F-fluorodeoxyglucose (F-FDG-PET) have examined the neurobiological basis of antipsychotic resistance in schizophrenia, primarily focusing on metabolic activity, with none investigating connectivity patterns. Here, we aimed to explore differential patterns of glucose metabolism between patients and controls (CTRL) through a graph theory-based approach and network comparison tests. PET scans with F-FDG were obtained by 70 subjects, 26 with treatment-resistant schizophrenia (TRS), 28 patients responsive to antipsychotics (nTRS), and 16 CTRL.
View Article and Find Full Text PDFVolume-regulated anion channels (VRACs) are multimeric proteins composed of different paralogs of the LRRC8 family. They are activated in response to hypotonic swelling, but little is known about their specific functions. We studied two human individuals with the same congenital syndrome affecting blood vessels, brain, eyes, and bones.
View Article and Find Full Text PDFBackground And Objective: The role of prostate-specific membrane antigen (PSMA)-based positron emission tomography (PET)/computed tomography (CT) in addition to magnetic resonance imaging (MRI) for local staging of prostate cancer (PC) has been poorly addressed so far. Our aim was to assess the diagnostic accuracy of PSMA PET/CT and MRI, alone and combined, for detection of extraprostatic extension (EPE) and seminal vesicle invasion (SVI) in PC.
Methods: We conducted a multicenter retrospective study evaluating patients undergoing PSMA PET/CT and MRI before radical prostatectomy.
Article Synopsis
- Schizophrenia (SCZ) shows differences in brain structure and symptoms between men and women, suggesting distinct neurobiological factors linked to sex.
- The study analyzed MRI data from nearly 6,000 participants to explore the effects of sex and diagnosis on the shape of deep brain regions in individuals with SCZ compared to healthy controls.
- Results indicated that women with SCZ had more pronounced shape abnormalities than men, but there were no significant interactions between diagnosis and sex, highlighting the need for further exploration of sex-related differences in schizophrenia's neurobiology.
Artificial intelligence (AI) models can produce output that closely mimics human-generated content. We examined individual differences in the human ability to differentiate human- from AI-generated texts, exploring relationships with fluid intelligence, executive functioning, empathy, and digital habits. Overall, participants exhibited better than chance text discrimination, with substantial variation across individuals.
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- The study looked at how often people bleed during and after tooth extractions if they take certain blood thinners called DOACs.
- They found that more teeth taken out at once and other specific procedures made bleeding more common.
- Even though bleeding did happen more with some DOAC medications, it was usually mild and could be managed, and stopping the medication before surgery might help with bleeding right after the procedure.
Medication-related osteonecrosis of the jaw (MRONJ) is a drug complication that can occur in patients taking antiresorptive or antiangiogenic drugs. Although it is a well-documented disease, there is no widely accepted treatment. However, several therapeutic approaches have been proposed.
View Article and Find Full Text PDFPurpose: Immediate implant placement is a reliable solution to replace hopeless teeth, but this procedure may be associated to an increased risk of soft tissue complications in case of thin biotype. The use of tissue-level implants with a convergent transmucosal profile has been advocated to increase space for soft tissue, contributing to improve their stability and esthetics. The aim of this retrospective study was to evaluate the esthetic outcomes and the Patient-Reported Outcome Measures (PROMs) of immediately placed implants with a convergent transmucosal profile.
View Article and Find Full Text PDFObjectives: This retrospective study compared the outcomes of implants placed in alveolar ridge preservation (ARP) treated sites with those in spontaneously healed (SH) sites.
Materials And Methods: The study included patients presenting with one implant placed in an ARP-treated socket and one in an SH site. The primary outcome was the comparison of Marginal Bone Level Changes (MBLC).
Purpose Of Review: The goal of this review is to summarize the potential causes of anaphylaxis in the different holiday contexts, providing practical suggestions aimed to mitigate the stress challenged by allergic patients because of unfamiliar situations.
Recent Findings: A regard was reserved to potential food triggers, particularly uncommon ones and typical of certain destinations, and to arthropods responsible for anaphylaxis.
Summary: This review highlights the potential risk of anaphylaxis due to the unusual contexts more experienced during holidays (i.
Purpose: To assess if PSMA PET quantitative parameters are associated with pathologic ISUP grade group (GG) and upgrading/downgrading.
Methods: PCa patients undergoing radical prostatectomy with or without pelvic lymph node dissection staged with preoperative PSMA PET at seven referral centres worldwide were evaluated. PSMA PET parameters which included SUV, PSMA, and total PSMA accumulation (PSMA) were collected.
Oxidative stress and high levels of reactive oxygen species (ROS) are linked to various age-related diseases and chronic conditions, including damage to oral tissues. Dexamethasone (DEX), a widely used glucocorticoid in dentistry, can have side effects like increased ROS production and delayed wound healing. Resveratrol (RSV) is known for its antioxidant properties, but its limited bioavailability hinders its clinical use.
View Article and Find Full Text PDFBackground: Ruminants play an important role in economic sustenance in many developing countries. Abortion is one of the most important causes of economic losses in sheep livestock and, for this reason, it is very important to know, at an early stage, which pathogens caused abortion.
Aim: The aim of the study is to obtain data about the distribution of abortifacient pathogens in the Italian regions of Latium and Tuscany, the awareness of the distribution of infectious agents causing abortion could allow the development of an appropriate vaccination and prophylaxis plan, to avoid major economic losses.
Background: The present systematic review evaluated clinical and radiographic features and treatment outcomes of peri-implantitis-induced medication-related osteonecrosis of the jaws (Pi-MRONJ).
Materials And Methods: Literature search was performed in PubMed/MEDLINE, Cochrane CENTRAL, Web of Science, and Scopus databases. Studies reporting Pi-MRONJ were included.
Article Synopsis
- Restless legs syndrome (RLS) is a common sleep disorder that leads to an urge to move the legs and is particularly prevalent in patients with Parkinson's disease (PD), with a prevalence rate of around 20%.
- A systematic literature review analyzed data from 46 studies to identify the characteristics of PD patients with RLS, finding that these individuals tend to be female and experience more severe motor and non-motor symptoms, including sleep issues and cognitive challenges.
- The relationship between PD and RLS suggests a complex interaction, influenced by dopaminergic therapy, but other neurotransmitter systems may also be involved in the severity of symptoms experienced by PD-RLS patients.
Article Synopsis
- This study used machine learning to classify subtypes of schizophrenia by analyzing brain images from over 4,000 patients and healthy individuals through international collaboration.* -
- Researchers identified two neurostructural subgroups: one with predominant cortical loss and enlarged striatum, and another with significant subcortical loss in areas like the hippocampus and striatum.* -
- The findings suggest this new imaging-based classification could redefine schizophrenia based on biological similarities, enhancing our understanding and treatment of the disorder.*
Article Synopsis
- - Acquired aplastic anemia (AA) is a rare condition involving low blood cell counts and underdeveloped bone marrow, affecting 2-3 people per million in Western countries and more in East Asia.
- - Treatments for severe aplastic anemia (SAA) have improved significantly, with hematopoietic stem cell transplantation (HSCT) from a matched sibling donor considered the best first-line approach, although alternatives exist if a sibling donor isn't available.
- - A guideline developed by pediatric hematologists aims to assist healthcare professionals in diagnosing and managing AA in children, based on evidence gathered and discussions held during consensus conferences, including adaptations made due to the COVID-19 pandemic.
Secondary primary malignancies (SPM) have been reported after anti-BCMA or anti-CD19 chimeric antigen receptor (CAR)-T-cell therapies. While the cytotoxic effect of antecedent therapies, including chemotherapy and radiotherapy, has been well established, few data are available on risk related to CAR-T immunotherapies. The study aimed to analyse the incidence of SPM in 651 patients enrolled in the Italian prospective observational CART-SIE study.
View Article and Find Full Text PDFBackground: The increase in temperatures due to the current climate change dramatically affects crop cultivation, resulting in yield losses and altered fruit quality. Tomato is one of the most extensively grown and consumed horticultural products, and although it can withstand a wide range of climatic conditions, heat stress can affect plant growth and development specially on the reproductive stage, severely influencing the final yield. In the present work, the heat stress response mechanisms of one thermotolerant genotype (E42) were investigated by exploring its regulatory gene network.
View Article and Find Full Text PDFEarly life stress may induce synaptic changes within brain regions associated with behavioral disorders. Here, we investigated glutamatergic functional connectivity by a postsynaptic density immediate-early gene-based network analysis. Pregnant female Sprague-Dawley rats were randomly divided into two experimental groups: one exposed to stress sessions and the other serving as a stress-free control group.
View Article and Find Full Text PDFArtificial intelligence (AI) models can produce output that closely mimics human-generated content. We examined individual differences in the human ability to differentiate human- from AI-generated texts, exploring relationships with fluid intelligence, executive functioning, empathy, and digital habits. Overall, participants exhibited better than chance text discrimination, with substantial variation across individuals.
View Article and Find Full Text PDFIn the last decades, the development of PET/CT radiopharmaceuticals, targeting the Prostate-Specific Membrane Antigen (PSMA), changed the management of prostate cancer (PCa) patients thanks to its higher diagnostic accuracy in comparison with conventional imaging both in staging and in recurrence. Alongside molecular imaging, PSMA was studied as a therapeutic agent targeted with various isotopes. In 2021, results from the VISION trial led to the Food and Drug Administration (FDA) approval of [Lu]Lu-PSMA-617 as a novel therapy for metastatic castration-resistant prostate cancer (mCRPC) and set the basis for a radical change in the future perspectives of PCa treatment and the history of Nuclear Medicine.
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