Leveraging nuclear receptor mediated transcriptional signaling for drug discovery: Historical insights and current advances.

Nuclear receptors (NRs) are ligand-activated transcription factors that regulate gene expression in response to physiological signals, such as hormones and other chemical messengers. These receptors either activate or repress the transcription of target genes, which in turn promotes or suppresses physiological processes governing growth, differentiation, and homeostasis. NRs bind to specific DNA sequences and, in response to ligand binding, either promote or hinder the assembly of the transcriptional machinery, thereby influencing gene expression at the transcriptional level.

Impact of Nada Yoga Music Therapy on Anxiety and Quality of Life in Ovarian Cancer Patients: A Randomized Controlled Trial.

Background And Objective: Nada yoga is a complementary therapy known for its potential to reduce anxiety. This study aimed to assess the effects of nada yoga music on anxiety management and quality of life (QoL) in ovarian cancer patients undergoing chemotherapy.

Materials And Methods: In this randomized controlled trial, 58 ovarian cancer patients undergoing chemotherapy were recruited.

Dysplastic changes secondary to cytomegalovirus-induced Lipschutz ulcer: Unraveling complexity.

Lipschutz ulcer is a rare nonvenereal condition affecting predominantly young females who are not sexually exposed and can be triggered by various infectious agents, trauma, and drugs. It presents with single or multiple painful ulcers over labia minora, labia majora, vestibule, and lower part of the vagina and may be preceded by prodromal symptoms akin to influenza or mononucleosis. Diagnosis is based on specific criteria, which include age, ulcer characteristics, and absence of immunodeficiency.

Motivators, Preferences, and Aspirations of University Students about Studying Yoga: A Survey from India.

Introduction: University students' motivators and preferences for yoga as their course of study can influence their future as yoga instructors and therapists.

Materials And Methods: Six hundred and thirty-six students of both genders (251:385, male: female) from four North Indian universities offering graduate and postgraduate courses in yoga were the respondents to a convenience sampling survey about their preferences and motivators.

Results: The three most common reasons why students chose to study yoga were (i) "I can help many people through knowledge of yoga" (32.

Development and content validation of yoga module for the mental health of NICU mothers.

Background: Postnatal yoga has been found to be effective for maternal mental health management. But a validated yoga module for the mental health of early postpartum mothers with infants admitted to the Neonatal Intensive Care Unit (NICU) is lacking.

Aim: To design and validate a yoga module for the mental health of early postpartum mothers having infants admitted to the NICU.

Subclinical right ventricular dysfunction in patients with asymptomatic type 2 diabetes mellitus: A cross-sectional study.

Background: Diabetic cardiomyopathy, which involves both the right and left ventricles, progresses from a preclinical stage to overt heart failure. Detection of this entity at a preclinical stage could be crucial in intervening to halt its progression to overt heart failure. There is a paucity of literature on subclinical RV dysfunction in diabetic patients, and it is even rarer in the Indian literature.

A Cross-sectional Survey to Assess Knowledge, Attitude, and Practice of Yoga among Cancer Patients at a Tertiary Care Hospital.

Background: Cancer incidence and mortality are rapidly growing worldwide. Cancer affects the overall quality of life of cancer patients. Yoga has its origin in the ancient times.

Predictability of Nailfold Capillaroscopic Score in Diagnosing Retinopathy in Patients with Type 2 Diabetes Mellitus and its Utility as a Non-Invasive Tool for Differentiating from those Not Having Retinopathy: A Pilot Observational Cross-Sectional Analytical Study.

Background: Diabetes mellitus (DM) is a chronic hyperglycaemic state associated with microvascular structural alterations. Nailfold capillaroscopy (NFC) is an study of microvascular circulation.

Aims And Objectives: This study aimed to investigate the diameters of capillary loops and morpho-structural changes using a handheld dermatoscope in patients with type 2 DM (T2DM) with and without diabetic retinopathy (DR) and to establish nailfold capillary changes and NFC score as a non-invasive method to identify microvascular complication in T2DM patients.

Clinical outcome of testosterone supplementation assessed by andropausal male symptom scores in type 2 diabetes testosterone-deficient patients receiving testosterone compared to those not receiving testosterone: A nested case-control study.

Background And Aims: This study aimed to explore the proportion of andropause in male patients with type 2 diabetes using an aging male symptoms scale and assess the clinical outcome of testosterone supplementation in patients with deficient testosterone levels at a tertiary care hospital.

Methods: Male patients with diabetes and total serum testosterone levels (≤12 nmol/L) were included in the study. Patients with testosterone supplementation, the standard of care among testosterone-deficient male patients, were included in the study (n = 35).

Creutzfeldt-Jakob Disease: A Case Report and Literature Review for Understanding the Big Picture.

Creutzfeldt-Jakob disease (CJD) is a rare, rapidly progressive neurodegenerative disorder that has an invariably fatal outcome. Aside from rapidly progressive dementia, this condition manifests as myoclonus, cerebellar, pyramidal, extrapyramidal, visual, and psychiatric symptoms. On the other hand, nonspecific symptoms might be difficult to diagnose, leading to a late or incorrect diagnosis.

Non-coding RNAs associated with autophagy and their regulatory role in cancer therapeutics.

Cancer widely affects the world's health population and ranks second leading cause of death globally. Because of poor prognosis of various types of cancer such as sarcoma, lymphoma, adenomas etc., their high recurrence and metastasis rate and low early diagnosis rate have become concern lately.

The Impact of Mobile Health Interventions on Antenatal and Postnatal Care Utilization in Low- and Middle-Income Countries: A Meta-Analysis.

Despite many efforts, the utilization of full antenatal and postnatal care remains a significant concern in low- and middle-income countries (LMICs). We planned to retrieve the relevant literature and pooled the data for meta-analysis to evaluate the impact of mobile health (mHealth) intervention on antenatal and postnatal care utilization in low- and middle-income countries. We searched the literature through major electronic databases such as PubMed, MEDLINE, Embase, Cochrane, Scopus, CINAHL, Clinical key, Google Scholar, and Ovid with selected keywords and explored the reference list of articles.

Hypoglycemia: Elucidating its circadian propensity and recovery time based on clinical parameters.

Background: Hypoglycemia is frequently associated with insulin therapy in diabetic patients; it leads to many short and long-term complications and even death if not addressed in time. This study was undertaken to observe the circadian propensity of hypoglycemia and its recovery time based on type 2 diabetes mellitus patients' clinical parameters.

Methods: We included type 2 diabetes mellitus (DM) hospitalized patients with the exclusion of patients suffering from critical illness.

Role of sequential chemical peel in cutaneous amyloidosis: a pilot case series.

Cutaneous amyloidosis can be a part of a systemic disease or can result from a localized process limited to the skin. It usually presents as pruritic hyperpigmented macules, papules or nodules, which are notoriously resistant to treatment. We performed a hospital-based pilot case series to assess the efficacy and safety of sequential salicylic acid (SA) and glycolic acid (GA) chemical peels.

Prevalence and predictors of depression in type 2 diabetes mellitus.

Background: Type 2 diabetes mellitus (DM) is a multifactorial disease and can be described as a noncommunicable disease of epidemic magnitude. Little is known about the predictors of depression in this population, especially among the Indian population. This study explores the predictors for depression in patients with type 2 DM.

Mycosis Fungoides: Uncommon Presentation.

Mycoses fungoides is a common cutaneous T cell lymphoma. Tumor and ulcerative stages are advanced lymphoma. We report a case of mycosis fungoides that presented with ulcerated plaques and nodules over the body and infraorbital region, he was being treated as leprosy without improvement of the lesions.

Autologous non-cultured keratinocyte cell suspension in non-healing diabetic ulcers: A preliminary study.

Background: Diabetic ulcers are a common morbidity associated with poorly controlled glycemic status. Most patients often have neuropathy and vasculopathy as the etiology behind such ulcers. These factors not only lead to poor wound healing but also nonhealing ulcers.

Study of self-generated magnetic fields in laser produced plasmas using a three-channel polaro-interferometer.

Self-generated magnetic fields produced in laser plasmas at moderate laser intensities have been measured using a three-channel polaro-interferometer. The main elements of this device are two birefringent calcite wedges placed between two crossed polarizers. Using this device, the spatial profiles of (a) the rotation angle (polarometry), (b) the electron density (interferometry), and (c) the transmitted probe beam intensity (shadowgraphy) are recorded simultaneously using a digital camera with a large format CCD in a single laser shot.

Effect of autologous epidermal cell suspension transplantation in chronic nonhealing wounds: a pilot study.

Background: Chronic nonhealing wounds are difficult to manage. Various substances are being used to heal these wounds. We sought to observe the effects of autologous epidermal cell suspension dressings on chronic nonhealing ulcers.