Increased sleep duration precedes the improvement of other symptom domains during the treatment of acute mania: a retrospective chart review.

Background: Understanding trajectories of symptom changes may help gauge treatment response and better identify therapeutic targets in treatment of acute mania. We examined how symptoms of sleep disturbance, mania, and psychosis resolved in a naturalistic treatment setting, hypothesizing that improvement in sleep would precede improvement in manic and psychotic symptoms.

Methods: Charts of 100 patients with admitting diagnoses of bipolar mixed or manic episode were retrospectively reviewed.

Frequency of reporting of adverse events in randomized controlled trials of psychotherapy vs. psychopharmacotherapy.

Background: Psychopharmacology and psychotherapy are the two main therapies in mental health. It is common practice to consider adverse events (AEs) of medications, but it's not clear this occurs with psychotherapy.

Aim: This study investigates the frequency with which reports of AEs occur in clinical trials using either psychopharmacology alone, psychotherapy alone, or combined approaches.