A phase I trial of cyclosporine for hospitalized patients with COVID-19.

BACKGROUNDCOVID-19 remains a global health emergency with limited treatment options, lagging vaccine rates, and inadequate healthcare resources in the face of an ongoing calamity. The disease is characterized by immune dysregulation and cytokine storm. Cyclosporine A (CSA) is a calcineurin inhibitor that modulates cytokine production and may have direct antiviral properties against coronaviruses.

Relationships Between Neuromuscular Function and Functional Balance Performance in Firefighters.

The purpose of the present study was to examine the relationships between neuromuscular function and functional balance performance in firefighters. Fifty career firefighters (35.1 ± 7.

The Influence of Habitual Protein Intake on Body Composition and Muscular Strength in Career Firefighters.

Objective: The aim of this research was to determine the relationship among protein (PRO) intake, body composition, and muscle strength in overweight and obese firefighters. A secondary objective was to evaluate differences in body composition and muscle strength among overweight and obese firefighters with low (L; < 0.8 g·kg), moderate (M; 0.

The influence of subcutaneous fat on the relationship between body composition and ultrasound-derived muscle quality.

Ultrasound echo intensity (EI) values are a popular assessment of muscle quality. The relationship between EI and total (%fat) and regional (%fat) body composition was examined in 40 men, prior to and after accounting for subcutaneous fat thickness. Uncorrected EI values suggest that muscle quality improves (r = -0.

Influence of Lower Extremity Muscle Size and Quality on Stair-Climb Performance in Career Firefighters.

The purpose of this study was to examine the influence of lower extremity muscular size and quality on stair-climb performance (SCP) in career firefighters. Forty-six male career firefighters (age = 37.0 ± 7.