Do stimulant drugs improve the academic performance of hyperkinetic children? A review of outcome studies.

Stimulant drug studies based primarily on measures of teacher opinion have frequently concluded that these drugs improve the achievement of hyperkinetic children. However, a review of those studies using more objective measures of academic performance revealed few positive short-term or long-term drug effects on these measures. What few improvements have been noted can be readily attributed to better attention during testing.

The effects of methylphenidate on various types of activity level and attention in hyperkinetic children.

The effects of methylphenidate on a number of objective measures of activity level and attention were assessed on three repeated occasions in four types of settings: free play, movie viewing, testing, and restricted play periods. Subjects were 36 boys between 5 and 12 years of age and of average intelligence. Of these, 18 were diagnosed as hyperkinetic and participated in a double-blind drug-placebo crossover design.

Environmental trace analysis of organics in water by glass capillary column chromatography and ancillary techniques. Products of ozonolysis.

A method employing a polymeric sorbent has been used for analysis of volatile organic components in water. Trace level organics are sparged from water with nitrogen gas and are concentrated on Tenax GC prior to analysis with either flame ionization gas chromatography or gas chromatography-mass spectrometry. Glass capillary columns were used to obtain maximum resolution of chromatographic peaks.

Predicting the response of hyperkinetic children to stimulant drugs: a review.

The present review examines 36 previous research reports involving over 1,400 hyperkinetic children in an effort to determine which variables have proven useful in predicting which hyperkinetic children will respond favorably to stimulant drugs. The research is summarized under eight types of predictor variables: (1) psychophysiological, (2) neurologist, (3) familial, (4) demographic/sociological, (5) diagnostic category, (6) parent/teacher/clinician ratings, (7) psychological, and (8) profile types. The results of this review indicate that, to date, measures of attention span or concentration and its correlates have proven to be the most useful predictors of the response of hyperactive children to drugs.

A comparison of objective measures of activity and distractibility in hyperactive and nonhyperactive children.

In a 15-minute free-play and a 5-minute test session, 13 measures of activity, distractibility, and parental ratings of activity were obtained on three groups of children, consisting of 16 boys referred to a psychological services center for evaluation of possible hyperactivity, 16 referred to that same center for problems other than hyperactivity, and 20 obtained from the local community. Subjects were boys with average intelligence between the ages of 4 and 12 years. Results indicated that the multiple measures of activity and distractibility had significant but relatively low order correlations among themselves.

Isolation of Aeromonas species from clinical sources.

In a period of one year, in a general hospital, Aeromonas hydrophila was isolated from 13 patients and Aeromonas shigelloides from one patient. Eight of the patients had superficial infections, two had urinary tract infections, and four had bacteriaemia. The association of Aeromonas bacteriaemia with cirrhosis of the liver and malignant disease, which has been previously reported, was observed in three of the four bacteriaemic patients.