[Influence of Low-Frequency Electromagnetic Field on DNA Molecules in Water Solutions].

It is shown that the amplicons of hepatitis virus DNA (hepatitis B virus, hepatitis C virus) are capable of inducing radiation after an exposure to electromagnetic fields in the frequency range from 3 to 30 Hz and the field strength, 24-40 A/m, registered by means of a chemiluminescence method. The most effect of the electromagnetic field on water solutions of the amplicons of hepatitis virus DNA occurs at the frequency of 9 Hz, the change in the hydration shell of DNA amplicons is observed. It is suggested that the change in the hydration shell of DNA amplicons exposed to the low-frequency electromagnetic field leads to restoration of hydrogen bonding, stitchings formation and DNA repair as a whole.

Random coil conformation of a Gly/Ala-rich insert in IkappaB alpha excludes structural stabilization as the mechanism for protection against proteasomal degradation.

Peptide segments of multiple glycine and alanine residues prevent the proteolytic degradation of ubiquitinated proteins by the proteasome. The structure of a Gly/Ala-rich insert in IkappaB alpha was probed by nuclear magnetic resonance (NMR) spectroscopy, comparing IkappaB alpha samples with and without Gly/Ala-rich insert. Narrow 1H-NMR resonances at chemical shifts indicative of random coil conformations were observed in the difference spectrum.