SIRT2 deacetylates and decreases the expression of FOXM1 in colon cancer.

New FOXM1-specific inhibitors with the potential to be used for therapeutic purposes are under extensive research. We hypothesized that deacetylation of FOXM1 would decrease protein expression, thus providing novel therapeutic management of colon cancers. Immunostaining was used to determine FOXM1 and SIRT2 expressions in human colon cancer tissue microarrays (n = 90) from Stage I to Stage IV.

Ionic Liquid-Solidified Floating Organic Drop Microextraction for the Preconcentration of Lead in Environmental Water Samples Prior to Its Determination with Electrothermal Atomic Absorption Spectrometry.

This research investigates the utilization of an ionic liquid combination of solidified floating organic drop micro-extraction (IL-SFODME) to augment the concentration of trace amounts of lead, working as a preliminary stage before electrothermal atomic absorption spectrometry (ETAAS) analysis without the use of chelating agents. Key parameters impacting the microextraction efficiency-including pH, the volume of the ionic liquid (1-Hexyl-3-methylimidazolium hexafluorophosphate, HMIMPF6), temperature, extraction time, and stirring speed-were methodically examined to determine optimal conditions. Under detected optimized conditions, an enhancement factor of 71.

Blocking SIG1R Along with Low Cadmium Exposure Display Anti-cancer Qualities in Both MCF7 and MDA-MB-231 Cells.

Sigma-1 receptor (SIG1R) is a chaperone that modulates inositol 1,4,5-trisphosphate receptor type1 (IPR1) calcium (Ca) channels on the endoplasmic reticulum. Therefore, SIG1R functions as an indirect regulator of Ca and acts as an apoptosis modulator. Increased expression of SIG1R is associated with poor prognosis in breast cancers (BC), and SIG1R antagonists like BD1047 induce apoptosis.

Long-term impact of sleeve gastrectomy on serum uric acid levels.

Background: Obesity is a risk factor for hyperuricemia. Bariatric surgery is an effective treatment method for metabolic control. The aim of our study was to evaluate the correlation between the preoperative and postoperative serum uric acid levels with body mass index, body weight, and excess weight loss in patients that underwent sleeve gastrectomy.

Potential associations between alterations in gut microbiome and obesity-related traits after the bariatric surgery.

Background: This study aimed to examine the effects of both obesity and bariatric surgery on gut microbiome, dietary intake, as well as metabolic and inflammatory parameters.

Methods: All participants (15 with morbid obesity who had bariatric surgery, 8 with morbid obesity and 11 non-obese) were followed up for a 6-month period with interviews at baseline (M0), at the end of 3 (M3) and 6 months (M6). Dietary assessment was done, and blood and faecal samples were collected.

Effects of different intraabdominal pressures on internal jugular vein, liver and kidney functions in obese patients undergoing laparoscopic sleeve gastrectomy.

Objective: The aim of this study was to investigate whether there was a difference in laparoscopic sleeve gastrectomy (LSG) performed with either 10 mmHg or 13 mmHg intraabdominal pressures. Effects of these pressures on the internal jugular vein (IJV) diameter and flow along with the liver and kidney function tests were evaluated.

Materials And Methods: The patients were divided into two groups with respect to the intraabdominal pressure performed during LSG (either 10 or 13 mmHg).

Analysis of the Effect of Weight Loss on Eustachian Tube Function by Transnasal Videoendoscopy.

Objective: To investigate the effect of weight loss after bariatric surgery on eustachian tube (ET) function with video endoscopy.

Materials And Methods: The present study was conducted as a prospective cohort and was completed with 19 patients. Three-step tympanometry (basal, Toynbee, Valsalva), dynamic slow-motion video endoscopy, and the Eustachian Tube Dysfunction Questionnaire-7 (ETDA-7) were applied to the patients preoperatively before bariatric surgery and in the postoperative 6th month.

Acoustic parameter changes after bariatric surgery.

Objective: To investigate the acoustic parameter changes after weight loss in bariatric surgery patients.

Materials And Methods: This prospective, longitudinal study was conducted with 15 patients with planned bariatric surgery, who were evaluated pre-operatively and at 6 months post-operatively. Fundamental frequency (F0), Formant frequency (F1, F2, F3, and F4), Frequency perturbation (Jitter), Amplitude perturbation (Shimmer) and Noise-to-Harmonics Ratio (NHR) parameters were evaluated for /a/, /e/, /i/, /o/, and /u/ vowels.

Whole mitochondrial genome of long-clawed mole vole (Prometheomys schaposchnikowi) from Turkey, with its phylogenetic relationships.

The mitogenome of Prometheomys schaposchnikowi was characterized for the first time as a circular DNA molecule (16.284 bp), containing 37 coding and 2 non-coding regions. In the mitogenome, ND6 and 8 tRNA genes were encoded on the light chain, while 12 PCGs, 14 tRNAs, 2 rRNAs, D-loop and O were encoded on the heavy chain.

A novel simplified scoring system for predicting mortality in emergency colorectal surgery: prediction model development.

Background: Despite advances in surgical approaches, emergency colorectal surgery has high mortality and morbidity.

Objective: We aimed to create a simple and distinctive scoring system, for predicting mortality among patients undergoing emergency colorectal surgery.

Design And Setting: Prediction model development study based on retrospective data-gathering.

External validation of anastomotic leakage risk analysis system in patients who underwent colorectal resection.

Background/aim: One of the most feared complications after colon resection for carcinoma is anastomotic leakage. Prediction of anastomotic leakage can alter pre- and perioperative management of patients. This study validates an anastomotic leakage prediction system.

Simplified scoring system for prediction of mortality in acute suppurative cholangitis.

Our objective in this study was to identify the factors contributing to mortality in acute suppurative cholangitis which could be tested easily in every emergency clinic. This is a retrospective study enrolling 104 patients with acute suppurative cholangitis. Demographic and laboratory data were collected for analysis.

Predictors of central lymph node metastasis in papillary thyroid cancer.

Introduction: Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid gland and although PTC has excellent prognosis, central lymph node (CLN) metastases are not uncommon. Studies have shown that CLN metastases are associated with an increased recurrence rate. The necessity for prophylactic CLN dissection (pCCND) in clinical lymph node negative (cN0) patients remains controversial.

Clinical course of incidental parathyroidectomy: Single center experience.

Objective: Thyroidectomy is a very common surgical procedure. Regardless of surgeon experience, incidental parathyroidectomy is a complication of thyroidectomy. The aim of this study was to identify the clinical course of incidental parathyroidectomies after thyroidectomy.