[Permeability of rat neurohypophysial blood vessels for neurophysins and ferritin in acute hyperoxia].

The time course of the release of vasopressin-binding (nicotine-stimulated) and oxytocin-binding (estrogen-stimulated) neurophysins (NPs) into the rat pituitary and blood serum has been studied during the convulsive phase of hyperbaric oxygenation (HBO) and the postconvulsive period (PCP). The ultrastructure of the posterior pituitary (neurohypophysis) and the state of the blood-pituitary barrier in the caudal region of the gland have been studied with the use of ferritin as an exogenous marker of vascular permeability.

[Ultrastructural changes of gastric superficial epithelium cells in chronic Helicobacter gastritis].

Electron-microscopic investigations were carried out in 22 specimens of biopsy material from pyloric and fundal parts of the stomach in patients with chronic Helicobacter gastritis. In 6 cases of normal mucosa Helicobacter pylori (HP) was absent both in the antrum and fundus. In chronic antral gastritis HP was found in both regions.

[Coccoid forms of Helicobacter pylori and their role in human pathology].

Most helocobacteria die as a result of eradication therapy. However, a negligible amount of them revert to the non-cultivated state and remain in the form of coccoids. Based on the literature analysis it has been proved that coccoid forms of H.

[Role of genetic features of Helicobacter pylori in development of inflammation of the gastric mucosa in chronic gastritis and ulcer disease].

This review, which is devoted to the analysis of current data on genetic properties of Helicobacteria, is the first work in the Russian literature summarizing the research results published before and after the sequencing of the genome of two Helicobacter pylori pathogenic strains--26695 and J99. It discloses information about the genetic control of pathogenecity factors and their localization on the chromosome. There is a review of genes participating in the colonization of Helicobacteria, lipopolysaccharide biosynthesis, urease synthesis, and pH control.

[Problem of antibiotic-resistant Helicobacter pylori and ways of overcoming it].

Application of non-drug treatment methods along with the basic drug therapy can promote the overcoming of antibiotic resistance and contribute to the eradication of H. pylori.

[Ultrastructural changes of child rib cartilage in different deformations of chest cells].

Different chest deformations are accompanied by appearance of asbestos-like fibrills in pericellular matrix, development of significant lipid and carbohydrate chondrocyte dystrophy, irreversible changes in their majority. Anomalous accumulation of intermediate filaments, lipid and glycogen, may substitute the cytoplasm organells in Marfan's syndrome. Pathologic disturbances of costal cartilage, connected with ultrastructural changes of chondrocytes, intercellular substance and extracellular matrix are morphologic substrate of different chest deformations.

[Ultrastructure of renal cortex in suckling rabbits with experimental cholera].

Development of experimental cholera in suckling rabbits is associated with appearance of alterations in glomerular filtration and tubular reabsorption of renal cortex. Ultrastructural changes of nephrons appear in the adhesion period and progress 24 hours later. In this case, particular vulnerability of the kidneys is associated with insufficient development of principal stages both in the cavity and membrane digestion in the gut, therefore, the kidney plays a role of one of the components of the protein-splitting system in the organism.

[The ultrastructural bases of multiple organ failure in the pathogenesis of endotoxic shock].

The paper presents ultrastructural characteristics of polyvisceral lesions underlying organ insufficiency in endotoxin shock, demonstrates the role of initial intracellular changes in target organs in the mechanism of generalized disorders caused by endotoxin action.

[Histogenesis of the giant cells of the osteoclast type in anaplastic thyroid carcinoma].

One case is reported of amphicrin thyroid carcinoma with signs of A- and C-cell differentiation. This tumor at its early stage had a follicular structure with massive deposits of amyloid in the stroma. In the course of progression the tumor transformed into C-cell anaplastic carcinoma with stromal amyloid deposits in the form of thin fibrils and production of polypeptide hormones and their precursors by tumor cells.

[The ultrastructural bases of disorders in the vascular plexuses of the lateral cerebral ventricles in rats under the action of endotoxin].

Using method of electron microscopy, the ultrastructural changes in epithelium and capillaries of the vascular plexuses of the brain lateral ventricles in rats after intravenous administration of E. coli endotoxin were studied. The dynamics of ultrastructural disorders during endotoxemia and epithelial cells alterations depending on microcirculatory bed conditions were shown.

[Structural-functional changes in liver and brain in endotoxic shock (ultrastructural study)].

An additional clearance link forming the Kupffer's cell-hepatocyte microsystem that protects the body from endotoxemia was found in the early period of hepatic endotoxic shock. Sensory cortical neurons display dystrophic changes in the neurons of the sensory cortex and capillary exhibit hemodynamic disorders as plethora and enhanced permeability of the blood-brain barrier. In the intervening period of shock, there are first signs of block in the Kupffer's cell-hepatocyte system and drastically marked microcirculatory and dystrophic disorders.

[The effect of adrenoblockers on the ultrastructural changes in the epithelium and neural elements of the small intestine of suckling rabbits with experimental cholera].

Infant rabbits (10-12-day old) were infected with El Tor 5879 culture via stomach. During the period of cholera vibrio adhesion (within 4 hr) and twice on the following day the animals were injected intraperitoneally with alpha- and beta-adrenoblockers pyrroxan and obsidan. It was established that mono- or combined therapy with adrenergic blocking agents prevents the vibrio adhesion, cholera vibrios were detected mainly in the small intestine lumen.

[The effect of myelopid on the ultrastructural changes in the rat myocardium induced by an endotoxin].

Ultrastructural changes in the myocardial atria and ventricles have been studied in experiments on rats in the intermediate period of the endotoxin shock, on the stage of late endotoxemia and its correction with myelopid. It was established that 5 hours after endotoxin injection contractile disturbances and intracellular myocytolysis take place and growth of secretory activity is observed in atrial cardiomyocytes. Simultaneously vascular permeability increases.

[Ultrastructural changes in the interstitial cells of the kidney medullary substance in suckling rabbits with experimental cholera].

A culture of virulent selection of cholera vibrios L-top 5879 was introduced through the probe to suckling rabbits-pups 10 to 12 days old. Ultrastructural changes of interstitial cells and capillaries of kidney medulla were studied. During vibrio adhesion (4 hrs after the inaction) interstitial cells acquire dystrophic changes, lipid granules content reduces, while vascular permeability grows higher which suggests the presence of prostaglandin precursors elimination into blood flow.

[Ultrastructural changes in atria dna small intestines of suckling rabbits in experimental cholera].

10-12-day old suckling rabbits received intragastrically culture of V. eltor 5879 and the resultant ultrastructural changes in the small intestine, atrial cardiomyocytes and capillaries were studied. In the period of cholera vibrio adhesion (4 hours after the culture administration) epithelial cells underwent hydropic degeneration.